Primary Ewing sarcoma (ES) of the lung is anecdotally rare, with few cases reported in literature. This report describes a 46 year-old man who presented with cough and chest pain. CT Thorax revealed a lesion in the right lung. Ultrasound guided fineneedle aspiration of the mass and subsequent cytologic examination exhibited a small round cell morphology. Immunohistochemistry done on the cell block revealed CD 99 and FLI-1 positivity, confirming the diagnosis of ES. FISH supported the diagnosis, showing the EWSR1 rearrangement. Radiologic investigations ruled out a primary tumour elsewhere, confirming the diagnosis of primary pulmonary ES. The patient was started on chemotherapy.
Pediatric surgeons or surgical oncologists usually do not encounter many patients that require hepatectomy for malignancy compared to adult patients that require hepatic resection. Therefore, a wide technical gap exists between pediatric and adult hepatic surgery. However, the number of major adult liver resection cases has been recently increasing [1-3]. There have been at least 20 adult cases in which the liver hanging maneuver (LHM) was used at our institution. We report that LHM, so also, double hanging maneuver is a useful and safe technique for hepatectomy in pediatric cancer surgery.
Background
Rhabdoid tumors are rare, highly lethal neoplasms characterized by alterations of SMARCB1 gene in chromosome 22, which occurs in infants and children. Fine needle aspiration (FNA) is an effective technique to diagnose this tumor when combined with Immunohistochemistry (IHC) and molecular genetics. In this study, we describe four cases of renal and extra‐renal rhabdoid tumor of which three cases were diagnosed on FNA with IHC.
Materials and methods
The study includes four children with renal and extrarenal rhabdoid tumor retrieved from cytology archives. FNA was done with cell block, IHC, and cytogenetics. The cytomorphology with ancillary studies were reviewed along with histopathology which was available in 3 out of 4 cases.
Results
All the four cases had similar cytomorphologic features comprising of large cells having vesicular nuclei which can be central or eccentric with prominent nucleoli and abundant pale cytoplasm. Few cells had intracytoplasmic hyaline inclusion. Cell block with IHC confirmed the diagnosis in three cases. One case in which cell block could not be made the diagnosis was confirmed on biopsy with IHC.
Conclusion
Rhabdoid tumors are uncommon but aggressive neoplasms with poor prognosis. Our study highlights that they can be diagnosed accurately on FNA cytomorphology when combined with IHC on cell block.
Introduction
Neuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost‐effective for solid tumor diagnosis. This study aims to evaluate the role of FNAC in the diagnosis of various infantile solid tumors.
Methods
In this retrospective study, 61 cases of FNA of infant solid tumors were retrieved from the cytology archives over a period of 5 years from January 2013 to December 2017. Cytomorphology was studied and immunohistochemistry on cell block was performed wherever feasible. Histopathological correlation was done in 19 cases.
Results
Of the 61 cases studied, 60 cases were included in the study of which 35 were male and 25 were female. Infantile solid tumors constituted 7.3% of all pediatric solid tumors reported in cytopathology division of our Institute. The most common final diagnosis was NB (15, 25%) followed by HBL (13, 21.6%), WT (10, 16.6%), RMS (nine, 15%) and GCT (nine, 15%). The commonest site was abdominal‐pelvic (42, 70%). A definitive independent diagnosis could be made on FNA in 48 cases (80%). Follow‐up was done for 1.5 to 4 years (mean 26 months). The highest and lowest mortality was noted in NB (64.3%) and WT (12.5%) respectively.
Conclusion
This study concludes that FNAC can be adopted as a diagnostic modality in infant solid tumors.
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