Primary extranodal CD30-positive T-cell non-Hodgkin's lymphoma of the oral mucosa

Rosenberg, Antoine J.W.P.; Blesma, D.H.; Sie-Go, Daisy M. D. S.; Slootweg, Piet J.

doi:10.1016/s0901-5027(96)80013-0

Cited by 35 publications

(25 citation statements)

References 11 publications

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“…11 Both ALCL and LyP also have been reported in the oral mucosa. [12][13][14][15] An abundance of eosinophils does not seem to be an inherent characteristic of the oral lesions, since only 1 of these cases was accompanied by a dense eosinophilic infiltrate and was, in fact, initially thought to represent an eosinophilic granuloma of the oral mucosa. 12 Interestingly, in our case 2, the striking eosinophilia observed at the oral site was not present in the skin nodule, raising the possibility that, rather than being a feature related to the tumor cells, it might only be the result of local (mucosal) factors.…”

Section: Discussionmentioning

confidence: 96%

“…A few cases with morphologic, immunophenotypic, and clinical courses similar to the lesions affecting the skin have been described in the oral mucosa. [12][13][14][15] We describe 3 patients who manifested oral mucosal lesions with features of TEG and with CD30+ atypical mononuclear cells. Their lesions were evaluated histologically, by immunohistochemical analysis, and by polymerase chain reaction (PCR) molecular analysis of the T-cell receptor (TCR)γ chain gene.…”

Section: Introductionmentioning

confidence: 99%

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Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

et al. 2004

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We describe 3 patients who had oral mucosal lesions with features of traumatic eosinophilic granuloma (TEG) and containing CD30+ atypical cells. In 1 patient, the oral lesion was followed by skin nodules. All lesions were evaluated histologically, by immunohistochemical analysis, and by polymerase chain reaction (PCR) analysis of the T-cell receptor (TCR) gamma chain gene. All oral lesions were characterized by a dense and deeply infiltrative lymphoproliferation, showing epitheliotropism and massive eosinophilia. They contained atypical large lymphoid cells, which expressed T-cell markers and CD30. PCR analysis showed a monoclonal rearrangement of the TCR gamma chain gene in all lesions and, in 1 patient, the same rearrangement in the oral and cutaneous specimens. The lesions in these patients seem to be the oral counterpart of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders and should be recognized as such to avoid a diagnosis of large T-cell lymphoma and possible consequent overtreatment. However, they represent only a subset among several others within the complex and heterogeneous category of disorders referred to as TEG.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Eosinophil-Rich CD30+ Lymphoproliferative Disorder of the Oral Mucosa

et al. 2004

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“…Indolent CD30-positive T-cell lymphoproliferations have been reported previously in the oral cavity, especially the tongue, and variably designated traumatic ulcerative granuloma with stromal eosinophila, traumatic eosinophilic granuloma, eosinophilic ulcer of the oral mucosa and Riga (or Riga-Fede) disease. [11][12][13][14][15][16][17][18][19][20] These terms connote a reactive process. 17,19 Reports of seemingly similar processes have been described as lymphomatoid papulosis (in the absence of co-existing cutaneous disease) 21 or as T-cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive T-cell lymphoproliferative disorders

et al. 2012

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“…The relative proportions of these cells differs from case to case . Although a linkage between oral mucosal EU and cutaneous CD30-positive lymphoproliferative disease have been suggested ( 28,48 ) , in-depth investigations will be needed to clarify this hypothesis.…”

Section: Discussionmentioning

confidence: 99%