Primary gastric choriocarcinoma: Case report with review of world literature

Jindrak, K; Bochetto, Joseph F.; Alpert, Lesley

doi:10.1016/s0046-8177(76)80105-0

Cited by 83 publications

(26 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean age of the men was 62.4 years (median, 63 years; range, 32-83 years) and that of the women was 54.8 years (median, 63 years; range, 26-74 years). In the 51 previously reported patients, the PGC was most frequently located in the lower third of the stomach (41%; 21/51), followed by the middle third (37%; 19/51) and the upper third (22%; 11/51); the location frequently coincided with the location of the gastric adenocarcinoma [4]. The tumor sizes ranged from 2 to 18 cm (mean, 7.0 cm) in diameter, and nearly all the tumors were accompanied by macroscopic hemorrhage or necrosis.…”

Section: Results Of Pooled Analysismentioning

confidence: 83%

See 1 more Smart Citation

Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases

et al. 2005

View full text Add to dashboard Cite

rameters of PGCs were described in some of these reports, most of the conclusions were unreliable because of the small number of PGC cases analyzed.In the present study, we conducted a pooled analysis of 53 PGC cases, including 2 patients treated at the National Cancer Center Hospital East (NCCHE), to clarify the tumor characteristics and prognostic parameters of patients with PGC. Case reports Case 1A 74-year-old man complaining of loss of appetite and loss of body weight, for 9 months, visited the NCCHE. Laboratory data showed anemia (RBC, 369 ¥ 10 4 /mm 3 ; hemoglobin [Hb], 8.4 g/dl; hematocrit [Hct], 28.5%), hypoalbuminemia (serum albumin, 3.0 g/dl), and high serum carcinoembryonic antigen (CEA; 31.2 ng/ml; normal, 0-5 ng/ml).A gastrointestinal X-ray examination revealed an ulcerated lesion with a distinct elevation occupying the lower third of the stomach and invading the duodenum. The lesion was endoscopically diagnosed as a gastric cancer, and a biopsy specimen taken from its margin revealed well-differentiated tubular adenocarcinoma. A computed tomography (CT) scan and echography showed no evidence of liver metastasis at this time.A radical subtotal Billroth II gastrectomy with lymph node dissection, omentectomy, and partial resection of the pancreatic head was performed. Macroscopically, no signs of liver metastasis or retroperitoneal invasion were observed.The resected tumor was 11.5 ¥ 8.5 ¥ 5.0 cm in size. The tumor had extended to the serosa (T3) and had directly invaded the duodenum. A metastasis was found in one of the supragastric lymph nodes (N1). Grossly, the tumor was fungating (Fig. 1). Histologically, the tumor Abstract Primary gastric choriocarcinoma (PGC) is a rare tumor. In total, approximately 140 cases of PGC have been reported in the international medical literature. However, the clinical behavior, tumor characteristics, and prognostic parameters of PGC have not been clearly described. We conducted a pooled analysis to clarify the tumor characteristics and prognostic parameters in 53 patients with PGCs, including 2 patients treated at our hospital. The following variables were examined as potential prognostic factors: (1) sex, (2) age, (3) depth of invasion, (4) size, (5) histology, (6) nodal metastasis, (7) distant lymph node metastasis, (8) synchronous liver metastasis, (9) residual tumor, and (10) chemotherapy (not given or given). Univariate and multivariate analyses showed that the presence of residual tumor and synchronous liver metastasis and the absence of chemotherapy were significantly associated with an increased hazard rate (HR) of short overall survival (OS). Pooled analysis, including the two patients with PGC treated at our facility, demonstrated that the presence of a curative operation and chemotherapy, and the absence of synchronous liver metastasis were the strongest indicators of a favorable clinical course in patients with PGC.

show abstract

Section: Results Of Pooled Analysismentioning

confidence: 83%

“…Most PGCs have been reported to possess an adenocarcinoma component of variable extent, and pure PGC is especially rare [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases

et al. 2005

View full text Add to dashboard Cite

show abstract

“…In 1978, one additional case of gastric choriocarcinoma was r e p~r t e d .~ However, unlike the present case, the primary lesion in nearly two-thirds of these gastric tumors was partially or completely adenocarcinomatous. 16 Therefore, while we report the 29th case of primary gastric choriocarcinoma, our case represents only the 1 1 th in which the tumor was pure choriocarcinoma.…”

Section: Discussionmentioning

confidence: 79%

Primary gastric choriocarcinoma: Immunohistochemistry, postmortem documentation, and hormonal effects in a postmenopausal female

Wurzel

Brooks

1981

Cancer

View full text Add to dashboard Cite

A rare tumor, primary choriocarcinoma of the stomach, occurred in a post menopausal female. The diagnosis was confirmed by autopsy and by immunohistochemical demonstration of HCG in trophoblastic tumor cells. Theories concerning development of this neoplasm are briefly discussed. In addition, this postmenopausal case uniquely permitted examination of the hormonal effects of the tumor on target tissues without the clouding issue of normal menstrual hormones. It appears that the observed estrogen- and progesterone-related tissue responses were not mediated through the ovary; instead, direct tumor production of these hormones is implicated.

show abstract

“…This lesion is the precursor for several extraembryonic germ cell tumors (yolk sac tumor, choriocarcinoma) or embryonic tumor (teratoma). Several histogenetic mechanisms have been proposed since the last of the twentieth century to explain extragonadal choriocarcinoma in men [6]. The remnant of germ-cell that failure migration has been postulated for embryologically related to the urogenital ridge (mediastinum, retroperitoneum, urinary bladder, and prostate or pelvic region) [7].…”

Section: Discussionmentioning

confidence: 99%

Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

View full text Add to dashboard Cite

Clinical diagnosis of choriocarcinoma may be difficult in post-menopause or children and ectopic origin. According to its histologic origin, it is classified as gestational or nongestational choriocarcinoma. Gestational choriocarcinoma its origin derived from placental trophoblast and nongestational choriocarcinoma-derived from a germ cell. However, DNA and genetic analysis can be used to define the origin of choriocarcinoma. Usually, the DNA examination and genetic analysis have not been used widely in clinical services. In this case the diagnosis to considered as a primary nongestational choriocarcinoma just based on clinical and laboratory finding. This article is aimed to remind the doctors who treat cases choriocarcinoma and is no doubt in deciding whether the origin of the disease from gestational or nongestational should carry out an investigation DNA and genetic analysis.

show abstract

Primary gastric choriocarcinoma: Case report with review of world literature

Cited by 83 publications

References 7 publications

Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases

Primary gastric choriocarcinoma: two case reports and a pooled analysis of 53 cases

Primary gastric choriocarcinoma: Immunohistochemistry, postmortem documentation, and hormonal effects in a postmenopausal female

Choriocarcionoma in an Infantile Patient

Contact Info

Product

Resources

About