Primary gastric Hodgkin's lymphoma: A rare coincidence

Kilaru, Sindhu; Panda, Sucheta; Das, Harish Chandra; Sahoo, Naresh Kumar; Mohapatra, Debahuti; Mohapatra, Satya; Kolluri, Spoorthy

doi:10.1016/j.ctarc.2020.100194

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Classical cases of Hodgkin's lymphoma are Chronic Diarrhea in Hodgkin's Lymphoma positive for CD30 and CD15. Similar findings were seen in case by Kilaru et al 9 Our case was positive for CD 30 but negative for CD15, similar findings were seen in presented by Jung et al 8 Typical CHL may have CD-15 negative immunohistochemistry in about one-third of the cases. 10 Combination chemotherapy is used for treatment of Hodgkin's Lymphoma.…”

Section: Discussionsupporting

confidence: 91%

“…Contrast-enhanced CT scan, PET scan, endoscopy; both conventional and capsule and contrast radiography are used as initial radiological investigations for a suspected case of GI Lymphoma. 9 We performed CT chest, abdomen and pelvis with contrast, which showed findings consistent with Lymphoproliferative disease. Endoscopy and colonoscopy of our patient was also performed, but the results were inconclusive.…”

Section: Discussionmentioning

confidence: 99%

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Chronic Diarrhea: A rare presentation of Hodgkin’s Lymphoma

Furqan¹,

Khan

Ali³

et al. 2022

Pak J Med Sci

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Hodgkin’s Lymphoma is a cancer affecting the lymphatic system. There are two subtypes of Hodgkin’s Lymphoma: Nodular lymphocyte predominant (NLPHL) and classical Hodgkin’s Lymphoma which has further four types. It has a bimodal distribution and is more common among males. The most common presentation is painless swelling in the neck, armpit or groin region. Associated Symptoms include night sweats, unintentional weight loss, fever, persistent cough or dyspnea. Involvement of the gastrointestinal tract is a rare occurrence. Diagnosis is based on hematological, radiological and histochemical studies. Here we report a rare presentation of a 47-year-old male who presented with symptoms of loose stools, weight loss and fever. CT scan and abdominal lymph node biopsy findings were consistent with a lymphoproliferative disorder Patient was being managed in the line of malabsorption syndrome with possible underlying malignancy but his condition deterioted before the histological diagnosis was confirmed. Thus, this report highlights the importance having a consideration for Hodgkin’s lymphoma in the management of chronic diarrhea. doi: https://doi.org/10.12669/pjms.38.8.5452 How to cite this:Furqan S, Khan SA, Ali D, Badini K. Chronic Diarrhea: A rare presentation of Hodgkin’s Lymphoma. Pak J Med Sci. 2022;38(8):---------. doi: https://doi.org/10.12669/pjms.38.8.5452 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Chronic Diarrhea: A rare presentation of Hodgkin’s Lymphoma

Furqan¹,

Khan

Ali³

et al. 2022

Pak J Med Sci

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“…Gastric lymphomas are highly nonspecific in the digestive tract and can easily be misdiagnosed [21,22]. H. pylori infection can lead to the development of a variety of lymphomas, including gastric DLBCL, mantle cell lymphoma (MCL), Burkitt's lymphoma, and Hodgkin's lymphomas [23][24][25][26]. Hence, it is important to define in detail the histomorphological features caused by H. pylori infection in cases of H. pylori infection of the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Histopathological staging and differential diagnosis of marginal zone lymphoma of gastric mucosa-associated lymphoid tissue

Ge,

Wang,

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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The purpose of this study was to explore the histopathological staging and differential diagnosis of marginal zone lymphoma in gastric mucosa-associated lymphoid tissue (MALT lymphoma). We performed detailed histomorphology and immunohistochemistry investigations as well as genetic testing on endoscopic biopsy and endoscopic mucosal resection specimens from 18 patients with gastric MALT lymphoma. We found that gastric MALT lymphoma typically begins as a small, isolated area outside the lymphoid follicular mantle zone or proliferates in a multifocal, patchy manner, gradually spreads to the interfollicular zone, forming diffuse proliferation, invades the gastric mucosal glands, and infiltrates or proliferates into the center of peripheral reactive lymphoid follicles. Abnormally proliferating lymphocytes invade the surrounding lymphoid follicles, resulting in damage, atrophy, and disappearance of their normal follicles as well as of the gastric mucosa glands, forming diffuse proliferation. Redifferentiation and proliferation lead to the transformation of lymphocytes; that is, MALT transitions into highly invasive lymphoma. Based on our findings in this study, we propose the following five stages in the process of development and progression of gastric MALT lymphoma: the stage of cell proliferation outside the lymphoid follicular mantle zone; the stage of heterogeneous proliferative lymphoepithelial lesion; the stage of reactive lymphoid follicular implantation; the stage of lymphoid follicular clonal proliferation; and the stage of MALT transforming into highly invasive lymphoma. We examined the differential diagnosis of histopathological features at each stage. The clinicopathological staging of gastric MALT lymphoma can help clinicians provide accurate treatment and track malignant cell transformation, thus playing a significant role in controlling its development and progression.

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Primary Gastrointestinal Lymphoma: Clinicopathological Study: 10 Years Experience in a Tertiary Care Center in Southern India

Bhayani,

Rao,

Shah

et al. 2024

Gastroenterology, Hepatology and Endoscopy Practice

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Background: The gastrointestinal tract (GIT) is a common site for extranodal lymphomas, accounting for 10%–15% of all non-Hodgkin lymphoma cases and 30%–40% of extranodal lymphomas. Regarding the incidence of the various histological subtypes and areas of involvement, there is a lot of heterogeneity in the literature. This study looked into the anatomical distribution, histological subtypes, and locations of primary gastrointestinal tract lymphomas (PGL) that were seen at a tertiary referral hospital in Southern India. Materials and Methods: A retrospective analysis of 96 individuals who had been diagnosed with PGL over the course of 10 years (2012–2022) was done. We carried out an audit of the clinicopathological profile of patients with PGL diagnosed over a period of 10 years. All lymphomas were classified according to the World Health Organization’s 2008 classification. Results: Of the 96 patients with PGL, 74 (77%) were male. The most common site for PGL was the stomach (50%), followed by the terminal ileum (14.58%). The most common histological subtype was diffuse large B cell lymphoma (DLBCL), which was seen in 85.42% of the patients. The most common symptom was abdominal pain (51.04%). Rituximab–cyclophosphamide–doxorubicin–vincristine–prednisolone was the most commonly used treatment regimen (56.3%). Conclusion: In this large single-center retrospective study, we found that the pattern of distribution of PGLs in India is comparable to the Western literature in that the stomach is the most prevalent site of PGL and DLBCL is the most common histological subtype.

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Primary gastric Hodgkin's lymphoma: A rare coincidence

Cited by 3 publications

References 22 publications

Chronic Diarrhea: A rare presentation of Hodgkin’s Lymphoma

Chronic Diarrhea: A rare presentation of Hodgkin’s Lymphoma

Histopathological staging and differential diagnosis of marginal zone lymphoma of gastric mucosa-associated lymphoid tissue

Primary Gastrointestinal Lymphoma: Clinicopathological Study: 10 Years Experience in a Tertiary Care Center in Southern India

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