Primary Gastric Lymphoma: A Clinical and Therapeutic Evaluation of 82 Patients

Abstract

Eighty-two patients with primary gastric (IE, II1E, and II2E) non-Hodgkin's lymphoma according to the Musshoff's staging system were treated with combined modality including surgery with/without radiotherapy between January 1985 and December 1991. According to the Updated Kiel classification 54 had high-grade histologic subtypes and 28 low-grade. The strategy throughout the study was to resect primary tumor: all patients underwent gastrectomy, 40 subtotal and 42 total gastrectomy. The resection permitted complete surgical staging utilizing three pathologic features: disease confined within or beyond the serosa, negative/positive regional lymph nodes, and negative/positive surgical margins. If there was no evidence of these pathologic factors, the patients who underwent surgery alone received no further radiotherapy. On the other hand, all patients who presented at least one of three pathologic factors were treated with adjuvant radiotherapy after the resection. All except 14 patients presented at least one of the pathologic features and 50 (61%) patients had involvement of the whole gastric wall. Radiotherapy included the gastric bed and para-aortic lymph nodes and, for the patients, who had positive regional lymph nodes in combination with the complete involvement of the gastric wall, the irradiation included the whole abdominal approach. The complete response rate was 97% and the 9-year disease-free survival was 93%. All but one of the 5 relapses occurred within 18 months stressing the need for more specific staging. Gastric resection with/without radiotherapy may still represent the primary therapeutic procedure in early stage gastric non-Hodgkin's lymphoma.

Non-Hodgkin's Lymphoma of the Colon: Case Report

“…5,6 Fakat bizim olgumuzda olduğu gibi diffüz natürde veya multibl de olabilmektedir. 7 Tümörün kaynaklandığı hücre tipi ise çoğunlukla %80-85 oranı ile B hücre, %10-15 oranında ise T hücredir. 6 T hücreli lenfomaların prognozlarının daha kötü olduğu bildirilmektedir.…”

Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma

“…22 Moreover, colorectal EMZLs differ from gastric variants not only in terms of the etiologic infectious organism but also in terms of its clinical presentation and treatment. 23 The exact percentage of patients affected by clinically apparent multiorgan disease upon diagnosis is not known in colorectal EMZLs. Unlike previous observations on gastric EMZLs, 24,25 lymph node involvement was frequently found in our cases and 60% of patients with colorectal EMZLs were stage IV disease.…”

Spectrum of Pediatric gastrointestinal tumors with special reference to clinico-pathological findings.

“…In the present study, the most common presenting symptom was abdominal pain. Ahmed Morsi et al [10] and Pier Luigi Zinzani et al [11] also reported abdominal pain as commonest presenting symptoms. Regarding topographical distribution, the ileocaecal region was the most common involved site.…”