“…However, RT is consistently reported to improve local control of the disease [5, 19,38,65,81,83]. A comprehensive evaluation of the data published so far supports the view that combined surgery and CT are superior to surgery alone [6,14,15,19,27,28,45,52,55,[59][60][61]63,[65][66][67]69,71,74,80,82]. The rationale of adjuvant or complementary CT is based on the natural history of primary GI-NHL, in which 50% or more of relapses after surgery GI-NHL [5,6,8,10,26,3 1,38,40,59,72,77,8 1 ,83,84], * RT are extraabdominal [1,11,32,38,48,53,65,77], and the fact that high cure rates have been achieved with CT in diffuse histiocytic or diffuse large cell lymphomas [85,86], which is the most common subtype in primary GI-NHL.…”