Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Abstract

AIM:To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS:Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS:Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%. CONCLUSION:Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.

Primary gastric plasmacytoma associated with Helicobacter pylori infection: a report of two cases with different prognosis

“…Helicobacter pylori has been recognized as the most common cause of chronic gastritis and considered to be the putative causative agent of gastric and duodenal ulcers, gastric adenocarcinoma, and gastric extranodal marginal zone B cell lymphoma (eMZBL) of the MALT type [6]. A possible causal relationship between GP and the underlying H. pylori infection has also been reported [7,8].…”

Clinical Significance of Preoperative Inflammatory Parameters in Gastric Cancer Patients

“…Feldman et al14 reported that ESR and CRP were very highly correlated (P<0.001). High ESR also has been found to correlate with overall poor prognosis for various types of cancer, including Hodgkin's disease, gastric carcinoma, renal cell carcinoma, breast cancer and mucosa associated lymphoid tissue (MALT) lymphoma lymphoma 13,15. According to meta-analysis on renal cell cancer patients, ESR was revealed to be a better indicator of cancer-specific survival than CRP 16.…”

Characteristics of the Prevalence of Helicobacter Pylori in Some Rivers of Georgia Against the Background of the Infection Caused by H.Pylori

“…It was revealed that the infected individuals, who had various symptoms, including pain, did not suffer from the pain more than the individuals, who did not have an infection at all (RiazulHassan S 2007). This aggravates the condition more, as the infected part of the population is more likely to postpone a visit to the doctor, since their symptoms are not severe enough that increases the probability of infection spreading (Todorovic M, 2008,).…”