Clinical Significance of Preoperative Inflammatory Parameters in Gastric Cancer Patients

Abstract

PurposeChronic inflammation induces cancer and cancer induces local tissue damage with systemic inflammation. Therefore, the aim of this study is to investigate the potential relationship between the severity of inflammation and prognosis in cancer patients.Materials and MethodsThis study enrolled 220 patients from January 2002 to December 2006 who underwent gastric surgery. We evaluated the relationship between preoperative inflammatory parameters (erythrocyte sedimentation rate, neutrophil-to-lymphocyte ratio) and other clinicopathological factors. Survival outcomes were compared according to the extent of inflammation.ResultsSignificant elevation of erythrocyte sedimentation rate was related with old age, increased neutrophil-to-lymphocyte ratio, decreased hemoglobin, increased carcinoembryonic antigen, increased tumor size and advanced TNM stage. Neutrophil-to-lymphocyte ratio was significantly correlated with old age, increased erythrocyte sedimentation rate and advanced TNM stage. In the univariate analysis, elevated erythrocyte sedimentation rate and increased neutrophil-to-lymphocyte ratio had significantly poorer survival than those without elevation (all P<0.05). However, the multivariate analysis failed to prove erythrocyte sedimentation rate and neutrophil-to-lymphocyte ratio as independent prognostic factors.ConclusionsThe elevation of erythrocyte sedimentation rate and neutrophil-to-lymphocyte ratio were correlated with poor prognosis in the univariate analysis and there was a strong correlation between inflammatory parameters (erythrocyte sedimentation rate and neutrophil-to-lymphocyte ratio) and tumor progression. Thus, erythrocyte sedimentation rate and neutrophil-to-lymphocyte ratio are considered useful as follow-up factors.

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

“…Previous reports have indicated that chronic inflammation may be involved in the development of gastric cancer, since IL-17A and IL-17F are expressed by Th17 cells that mediate chronic inflammation and various diseases (Hu et al, 2013;Lee et al, 2013;Park et al, 2005). Previous studies have investigated the association between rs2275913G>A and rs763780T>C polymorphisms and the risk of gastric cancer, but the results have been inconsistent; therefore, we carried out a meta-analysis to investigate the association to obtain a reliable conclusion.…”

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

“…Previous reports indicated that chronic inflammation may be involved in the development of gastric cancer, because IL-17A and IL-17F are expressed by Th17 cells which mediate chronic inflammation and various diseases (Park et al, 2005;Hu et al, 2013;Lee et al, 2013). Thus far, some studies have investigated the association between IL-17A and IL-17F polymorphisms and susceptibility to gastric cancer, but the results were unclear.…”

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

“…It is generally known that chronic inflammation can play a critical role in the pathogenesis of gastric cancer (Merchant, 2005;Lee et al, 2013). Previous studies reported that the IL-17 gene is expressed by Th17 cells and modifies chronic inflammation, and SNPs in IL-17 may alter gene expression, thus changing protein function and contributing to cancer risk (Park et al, 2005;Dong et al, 2008).…”