Primary Gastrointestinal B-Cell Lymphoma - A Clinicopathological and Immunohistochemical Study of 61 Cases with an Evaluation of Prognostic Parameters

Krugmann, Jens; Dirnhofer, Stephan; Gschwendtner, Andreas; Berresheim, Ulrike; Greil, Richard; Kristine, Krugmann; Fend, Falko

doi:10.1078/0344-0338-00051

Cited by 21 publications

(18 citation statements)

References 42 publications

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“…Au terme du bilan d'extension, les lymphomes primitifs rectocoliques sont généralement diagnostiqués à des stades localisés classés I à II selon la classification de Ann-Arbor modifiée par Musshoff pour le tube digestif (Tableau 1) [6].…”

Section: Discussionunclassified

Lymphome diffus à grandes cellules B primitif du côlon transverse

Mnif¹,

Medhioub²,

Amouri³

et al. 2012

Acta Endosc

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La localisation rectocolique des lymphomes non hodgkiniens primitifs extranodaux demeure rare et ne repré-sente que 10-20 % des lymphomes gastro-intestinaux et 0,2-0,6 % des tumeurs malignes colorectales. Nous rapportons l'observation d'un homme âgé de 84 ans qui était hospitalisé pour exploration d'une constipation avec douleur abdominale. La coloscopie avait montré une lésion ulcérée du côlon transverse dont les biopsies avaient conclu à un lymphome B à grandes cellules. Le bilan d'extension était négatif. Le patient est décédé après trois cures de chimiothérapie. À travers cette observation et une revue de la litté-rature, nous discuterons les caractéristiques épidémio-logiques, clinicomorphologiques et thérapeutiques de cette entité rare. Pour citer cette revue : Acta Endosc. 42 (2012). Mots clés Lymphome non hodgkinien · Lymphome extranodal · Côlon · ChimiothérapieAbstract Rectocolonic localization of primitive extranodal non-Hodgkin lymphoma remains rare. It accounts for only 10-20% of gastrointestinal lymphomas and 0.2-0.6% of colorectal malignancies. We report the case of a patient aged 84 years who was admitted for exploration of constipation with abdominal pain. Colonoscopy revealed an ulcerated lesion of the transverse colon. Histological examination revealed a diffuse large B-cell lymphoma. The staging was negative. The patient died after three cycles of chemotherapy. Through this observation and the literature review, we discuss the epidemiological and clinical-morphological features and treatment of this rare entity. To cite this journal: Acta Endosc. 42 (2012).

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Section: Discussionunclassified

Lymphome diffus à grandes cellules B primitif du côlon transverse

Mnif¹,

Medhioub²,

Amouri³

et al. 2012

Acta Endosc

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“…In the large bowel, MALT lymphomas are mostly localized to distal bowel, rectum, and anus [8]. Histologically, of all the gastrointestinal lymphomas, a vast majority (35-44%) is constituted by low-grade marginal zone B-cell lymphoma of MALT type, followed by primary extranodal diffuse large Bcell lymphoma (DLBL) (22-45%) [9], DLBL plus MALT lymphoma (17%), DLBL without MALT lymphoma 22%, follicular lymphoma (5.9%), and T-cell lymphoma (9%); while other forms such as Burkitt lymphoma (1.3%), mantle cell lymphoma (0.4%), plasmacytoma (0.4%), and lymphoblastic lymphoma (0.8%) are exceedingly rare [5].…”

Section: Discussionmentioning

confidence: 99%

Extranodal Marginal Zone B-cell Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of Cecum Presenting as Bright Red Bleed per Rectum—A Case Report with Review of Literature

Mehta

Modi

Sapanara

et al. 2008

J Gastrointest Canc

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“…M Svrcek et al [19] found p53 positivity in 51.85% of small intestinal adenocarcinoma. Krugmann et al [20] reported p53 overexpression in 75% of small intestinal lymphomas. These differences may be due to the use of different scoring system and inter-observer variability.…”

Section: P53 Immunoexpression -Small Intestinementioning

confidence: 99%

“…Ge C et al [17] in their study showed that the degree of p53 protein expression was significantly correlating with the grade of the tumour cell differentiation, invasion, metastasis and prognosis. According to Krugmann et al [20] and Ming Qing et al [21] p53 overexpression in small intestinal lymphomas is a critical factor in the transformation of low grade MALT lymphoma and the overexpression also indicate the aggressive behavior of high grade tumours.…”

Section: P53 Immunoexpression -Small Intestinementioning

confidence: 99%