Primary Gastrointestinal Non-Hodgkin’s Lymphoma: I. Anatomic and Histologic Distribution, Clinical Features, and Survival Data of 371 Patients Registered in the German Multicenter Study GIT NHL 01/92

Abstract

PGI NHL are heterogeneous diseases. The number of localized PGL allowed for detailed analyses. Larger studies are needed for stages III and IV and for intestinal NHL. A uniform reporting system for PGI NHL, in terms of definitions and histologic and staging classifications, is needed to facilitate comparison of treatment results.

Primary gastrointestinal lymphoma in Japan

“…Similar results were reported by Ruskoné-Fourmestraux et al 18 and Koch et al 25 The poor prognosis of the combined group in our study may have been associated with more frequent T-cell phenotype and more advanced-stage disease. In three studies, 18,23,25 however, T-cell lymphomas were extremely rare. This discrepancy may correlate with the difference in the incidence of T-cell lymphoma between Western countries and Japan.…”

“…In our series, the gastric group comprised 75% of all patients. This percentage was similar to that in studies from Austria 17 and Germany 25 and the value is higher than that observed in NS: not significant. a P Ͻ 0.006 is significant using the Bonferroni correction.…”

“…However, most of these studies analyzed a small number of subjects and only five recruited more than 300 patients. 2,17,[23][24][25] The current study is the second largest series, which follows an earlier study by Freeman et al 2 Table 6 shows the primary site of gastrointestinal lymphoma in five studies, 2,17,[23][24][25] together with a larger population-based report by Gurney et al 37 The most common primary site was the stomach with a frequency ranging from 44% to 75%. In our series, the gastric group comprised 75% of all patients.…”

“…These differences may have been associated with the difference in response to treatment and patient survival. A better prognosis for gastric lymphoma compared with other localizations has been described previously, 1,4,8,11,17,18,21,24,25 although several authors showed no difference in the prognosis between gastric lymphoma and intestinal lymphoma. 5,9,[13][14][15]19,20,22,23 Few publications have shown prognostic data on patients with both gastric and intestinal involvement.…”

Methylation and API2/MALT1 fusion in colorectal extranodal marginal zone lymphoma

“…20 The overall incidence of EMZL in the intestine is quite low and accounts for only about 2.7% of all cases of gastrointestinal non-Hodgkin lymphomas. 21 Primary colorectal lymphoma accounts for only about 0.2% of large intestinal malignancies. 22 Moreover, colorectal EMZLs differ from gastric variants not only in terms of the etiologic infectious organism but also in terms of its clinical presentation and treatment.…”