Primary Gastrointestinal Non-Hodgkin’s Lymphoma: II. Combined Surgical and Conservative or Conservative Management Only in Localized Gastric Lymphoma—Results of the Prospective German Multicenter Study GIT NHL 01/92

Kang

et al. 2011

Blood

127

136

The aim of this retrospective cohort study was to analyze the impact of surgery on the outcomes and qualities of life (QOL) in patients with intestinal diffuse large B-cell lymphoma (DLBCL). We assessed 345 patients with either localized or disseminated intestinal DLBCL and compared them according to treatment: surgical resection followed by chemotherapy versus chemotherapy alone. In patients with localized disease (Lugano stage I/II), surgery plus chemotherapy yielded a lower relapse rate (15.3%) than did chemotherapy alone (36.8%, P < .001). The 3-year overall survival rate was 91% in the surgery plus chemotherapy group and 62% in the chemotherapy-alone group (P < .001). The predominant pattern in the chemotherapy group was local relapse (27.6%). When rituximab was used with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP), there was no improvement of the outcomes in patients treated with primary surgical resection. The QOL of patients who underwent surgery and chemotherapy was lower than chemotherapy alone, but its difference was acceptable. Multivariate analysis showed that surgical resection plus chemotherapy was an independent prognostic factor for overall survival. Surgical resection followed by chemotherapy might be an effective treatment strategy with acceptable QOL deterioration for localized intestinal DLBCL. This study was registered at www.clinicaltrials.gov as #NCT01043302. (Blood. 2011;117(6): [1958][1959][1960][1961][1962][1963][1964][1965]

Section: Discussionmentioning

confidence: 70%

Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone

Kang

et al. 2011

Blood

127

136

“…[13][14][15][16][17][18]30,31,45,46 Although past studies showed that surgical resectability was of significance, recent studies have demonstrated that nonsurgical strategies and surgery-based modalities had an equivalent efficacy. 30,31,45 Based on all these observations, and taking patients' quality of life into consideration, nonsurgical treatment is an alternative and optimal therapeutic modality for gastrointestinal lymphoma. Further randomized prospective studies with a large number of patients are still needed to establish …”

Section: Discussionmentioning

confidence: 99%

Primary gastrointestinal lymphoma in Japan

Nakamura

Matsumoto

Iida

et al. 2003

Cancer

245

Polymer particle agglomeration and melting causing sheet formation in fluidized bed reactors have been reported to occur during olefin polymerization. The cause of this deleterious sheet formation has not yet been established. Infrared and optical imaging were used to study the temporal temperature and size during polymerization of individual commercially active catalyst particles supported on a nylon mesh. Experiments conducted at 2100 kPa confirmed theoretical predictions that the temporal temperature rapidly attains a maximum after the start of the reaction. The magnitude of the temperature rise increases upon an increase of either reactor temperature, initial catalyst particle diameter, catalyst loading, or addition of hydrogen to the feed. The maximum transient temperature rise of single commercial catalyst particle during ethylene polymerization (7.5°C) is lower than that which can lead to local melting and polymer sheet formation. The temperature rise of particle clusters is much higher than that of individual particles, as the cluster acts as a particle with an effective diameter much larger than that of an individual particle. Thus, to circumvent polymer melting it is essential to avoid catalyst particles clustering, which may be caused by electrostatic attraction. The addition of hydrogen to the feed, often used to control polymer properties, significantly increased the initial particle temperature rise (almost double in some cases). © 2008 American Institute of Chemical Engineers AIChE J, 2008

“…Surgery has been abandoned in recent years. 12,13 Radiation therapy has been used either as sole treatment or as an adjunct to surgery and had produced good control of the disease in patients who have localized lymphoma. 14,15 Several prospective studies have produced encouraging results with chemotherapy, such as cyclophosphamide, chlorambucil, 2-chorodeoxyadenosine (2CdA), and combinations with fludarabine or other drugs.…”

mentioning

confidence: 99%

Combination therapy with rituximab and intravenous or oral fludarabine in the first‐line, systemic treatment of patients with extranodal marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue type

Salar

Domingo‐Domenech

Estany

et al. 2009

Cancer

Poly(3‐hexylthiophene)‐b‐poly(4‐vinylpyridine) diblock copolymer was synthesized by RAFT polymerization of 4‐vinyl pyridine using a trithiocarbonate‐terminated poly(3‐hexylthiophene) macro‐RAFT agent. The optoelectronic properties and the morphology of the block copolymer blends with CdSe quantum dots were investigated. UV‐vis and fluorescence experiments were performed to prove the charge transfer between CdSe and poly(3‐hexylthiophene)‐b‐poly(4‐vinylpyridine) diblock copolymer. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011