Primary Hepatic Leiomyosarcoma

Primary liver leiomyosarcoma: CT appearance

“…From the clinical point of view, hepatomegaly, a palpable abdominal or right upper quadrant mass, and upper abdominal quadrant pain are the usual presenting findings, due to the generally conspicuous dimensions of the tumor at the time of diagnosis [5,6]. In both of our patients, tumors developed in the right hepatic lobe, just as in the majority of other reported cases [4].…”

“…As a matter of fact, to assume the diagnosis of primary leiomyosarcoma of the liver, all other possible sites of origin, including the more frequent inferior vena cava and ligamentum teres, must be excluded by careful staging. The possibility that the liver may be secondarily involved by a contiguous lesion primarily located in the stomach, gallbladder, or diaphragm ought to be ruled out [5]. Hepatic smooth muscle cells tumors probably arise from hepatic veins or bile ducts.…”

Case of primary hepatic leiomyosarcoma successfully treated with laparoscopic right hepatectomy

“…Review of the literature reveals only about 76 cases of primary hepatic leiomyosarcoma reported 3–63. As in our case, an important prerequisite to its diagnosis is to exclude the possibility of an extrahepatic source of metastasis, with primary tumours being typically identified in the gastrointestinal tract, uterus or retroperitoneum 64–67…”

Primary Hepatic Leiomyosarcoma: a Case Report and Review of the Literature

“…However, there were four patients with tumors confined within the liver who underwent liver transplantation (25,27,39). Some authors reported the addition of adjuvant chemotherapy consisted of various combinations of drugs (6,8,10,23,28,30,31,35,37,39). Some of the administrated chemotherapeutic regimens were the following: 1. vincristine, cyclophosphamide and dactinomycin (8); 2. cyclophosphamide, vincristine and actinomycin D (10); 3. doxorubicin (23); 4. folinic acid, fluorouracil, irinotecan (FOLFIRI) and bevacizumab (30); 5. mitoxantrone, cisplatin and fluorouracil (35); 6. ifosfamide and mesna (37).…”