Primary Hepatic Lymphoma Masquerading as Symptomatic Hypercalcemia

Abstract

Primary lymphoma of the liver is extremely rare, and is more common among immunocompromised patients. It typically occurs after the fifth decade of life and has a male predominance. It often presents with diagnostic difficulties to both clinicians and pathologists as most cases have a solitary or multiple mass lesions in the liver with normal alpha-fetoprotein levels. Chemotherapy is the standard of therapy. Here, we describe a unique case of primary hepatic lymphoma in an elderly immunocompetent female who presented with symptomatic hypercalcemia.

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

“…Full blood counts are usually within the normal range unless the bone marrow or spleen is involved ( 38 ). Other occasional laboratory findings include monoclonal paraproteinemia and hypercalcemia, which is possibly the result of the secretion of calcitriol by lymphoma cells ( 39 , 40 ).…”