Primary Hepatic Lymphoma Presenting as an Acute Abdomen in a Young Female Patient: A Case Report and Literature Review

Abdelrahim, Walid Elhaj; Mohamed, Kamal Eldein Hamed; Mekki, Salwa O.; Saad, Eltaib

doi:10.1155/2019/6784325

Cited by 3 publications

(6 citation statements)

References 12 publications

(52 reference statements)

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“…However, a small number of patients may experience abdominal pain, fever, jaundice, nausea, poor appetite, and night sweats. [ 11 – 13 ] In the case of the patient described here, an elderly male, the liver mass was discovered during an evaluation for abnormal urination. There were no specific symptoms present.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma a case report and literature review

Jiang,

Yang

et al. 2023

Medicine

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Rationale: Primary hepatic lymphoma is a rare extranodal non-Hodgkin lymphoma that is primarily localized in the liver. It predominantly affects elderly males and presents with nonspecific laboratory findings, imaging results, and clinical symptoms, making diagnosis challenging. Histopathological examination serves as the gold standard for diagnosis, and treatment options include chemotherapy or surgical intervention combined with chemotherapy. Patient concerns: A 50-year-old male patient came to our hospital for treatment after finding a mass in his liver. Diagnoses: Laboratory tests and clinical symptoms lack specificity for primary hepatic lymphoma, and imaging findings can be difficult to differentiate. Pathology is the gold standard. Outcomes: The patient was dead. Conclusion: A definitive diagnosis primarily relies on histopathological examination, and surgical resection combined with chemotherapy yields better treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma a case report and literature review

Jiang,

Yang

et al. 2023

Medicine

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“…Therefore, the mean age of the initial diagnosis of lymphoma was 52.11 (±2. 19) years, whereas hepatic involvement by lymphoma was detected at a mean age of 56.6 (±13.08) years. Liver biopsy was ultrasound-guided in 29/36 (80.6%) cases and surgical in 7/36 (19.4%) cases.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Clinical and Pathological Characterization of Hepatic Lymphomas: A Retrospective Single-Center Study

Dias

Marques

Gonçalves

et al. 2023

Arq. Gastroenterol.

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Background: The incidence of hepatic lymphoma has been increasing recently and diagnosis can be challenging as clinical presentation and radiological findings are usually variable and non-specific. Objective The aims of this study were to describe their main clinical, pathological and imaging characteristics and identify poor prognostic factors. Methods A retrospective study that included all patients with histological diagnosis of liver lymphoma over a 10-year period at our center was performed. Results A total of 36 patients were identified, with mean age of 56.6 years and male predominance (58%). There were three patients with primary liver lymphoma (8.3%) and 33 with secondary liver lymphoma (91.7%). The most common histological type was diffuse large B-cell lymphoma (33.3%). The most common clinical manifestations included fever, lymphadenopathy, weight loss, night sweats and abdominal discomfort; three patients (11.1%) were asymptomatic. Computed tomography scan revealed heterogenous radiological patterns including a single nodule (26.5%), multiple nodules (41.2%) or diffuse infiltration (32.4%). The mortality rate during follow-up was 55.6%. Higher levels of C-reactive protein (P=0.031) and absence of treatment response (P<0.001) were significantly associated with higher mortality. Conclusion Hepatic lymphoma is a rare disease that may involve liver as part of a systemic disease or, less commonly, be confined to this organ. Clinical presentation and radiological findings are often variable and non-specific. It is associated with high mortality and poor prognostic factors include higher levels of C-reactive protein and absence of response to treatment.

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“…The imaging features of PHL are wide-ranging, and are commonly evaluated by abdominal ultrasound (US), CT, and MRI. At imaging, PHL can appear as a solitary mass, multiple lesions, or diffuse infiltration ( 41 ), mimicking other liver diseases, such as hepatocellular carcinoma, cholangiocarcinoma, metastatic disease of liver, and hepatitis.…”

Section: Primary Hepatic Lymphomamentioning

confidence: 99%

“…Major prognostic factors associated with survival are the large size of the tumor, high proliferation of cells, old age, systemic symptoms, unfavorable histologic subtype, disease stage, and complications ( 44 , 68 ). An elevated level of LDH, β2 microglobulin, or serum calcium, as prognostic markers, suggests a worse prognosis ( 41 ).…”

Section: Primary Hepatic Lymphomamentioning

confidence: 99%

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Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Wang

Wu²,

Zhang³

et al. 2022

Front. Oncol.

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Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.

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Primary Hepatic Lymphoma Presenting as an Acute Abdomen in a Young Female Patient: A Case Report and Literature Review

Cited by 3 publications

References 12 publications

Primary hepatic lymphoma a case report and literature review

Primary hepatic lymphoma a case report and literature review

Clinical and Pathological Characterization of Hepatic Lymphomas: A Retrospective Single-Center Study

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

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