Primary Hepatic Neuroendocrine Tumor: A Case Report and Literature Review

Elayan, Ahmad; Batah, Hamzeh; Badawi, Moath; Saadeh, Ahmad; Hafez, Sufian Abdel

doi:10.7759/cureus.22370

Cited by 5 publications

(22 citation statements)

References 17 publications

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“…Although uncommon, functional PHNETs can manifest symptoms associated with Zollinger-Ellison syndrome, Cushing's syndrome, or carcinoid syndrome. 4 Our patient was asymptomatic 3 months ago, but later had functional symptoms. The progression of the tumor over time can account for the transition from being asymptomatic to experiencing these symptoms.…”

Section: Discussionmentioning

confidence: 65%

“…A few patients may experience pain, abdominal distension, or jaundice due to the mass effect. Although uncommon, functional PHNETs can manifest symptoms associated with Zollinger‐Ellison syndrome, Cushing's syndrome, or carcinoid syndrome 4 …”

Section: Discussionmentioning

confidence: 99%

“…Surgical management of PHNETs shows the highest effectiveness to date, demonstrating a five‐year survival of 74% with 18% recurrence rate 8 . Medical treatments like Trans‐arterial chemoembolization, systemic chemotherapy, local ablation, and somatostatin analogs have not shown long‐term survival benefits 4 . Given the rarity of the disease, establishing treatment recommendations or a consensus is challenging.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Determining the precise incidence of primary NETs in the liver remains challenging due to the prevalence of neuroendocrine liver lesions that mainly develop from metastases, commonly originating from the gastroenteropancreatic system. 4 In this case report, we present a distinctive occurrence of a functional primary NET in the left lobe of the liver in an elderly woman, who underwent a left hepatectomy and experienced an extended period of postoperative recovery. The aim of reporting this case is to share our experience of dealing with an extremely uncommon clinical entity and highlight the importance of histopathology and immunohistochemistry in the diagnosis and emphasize that oncological resection, if feasible, is the preferred treatment even in the elderly population.…”

Section: Introductionmentioning

confidence: 91%

“…Primary neuroendocrine tumors (NETs) originating in the liver are extremely uncommon, with only around 200 reported cases documented globally 1–3 . Determining the precise incidence of primary NETs in the liver remains challenging due to the prevalence of neuroendocrine liver lesions that mainly develop from metastases, commonly originating from the gastroenteropancreatic system 4 …”

Section: Introductionmentioning

confidence: 99%

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Primary hepatic functional neuroendocrine tumor in an elderly female: Case report

Kushwaha,

Jaiswal,

Gupta

et al. 2023

Clinical Case Reports

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Key Clinical MessagePrimary hepatic neuroendocrine tumor, an exceptionally rare subtype, poses a diagnostic challenge. Oncological resections should be considered, even in elderly patients after following protocolized pre‐operative optimizations.AbstractNeuroendocrine tumors (NETs) are rare tumors that primarily develop in the gastrointestinal and respiratory tracts. While the liver is commonly affected by NET metastases, primary hepatic neuroendocrine tumors (PHNETs) are an exceptionally rare subtype. The characteristic slow growth and nonfunctional nature of PHNETs pose challenges in their diagnosis. Furthermore, PHNETs often exhibit a lack of unique radiological characteristics that differentiate them from other liver tumors, leading to frequent misdiagnosis as hepatocellular carcinoma. We performed left hepatectomy for PHNET in an elderly lady with prolonged stormy postoperative course. This case report of a PHNET highlights the importance of histopathology and immunohistochemistry in the diagnosis and emphasizes that oncological resection, if feasible, is the preferred treatment even in the elderly population.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Primary hepatic functional neuroendocrine tumor in an elderly female: Case report

Kushwaha,

Jaiswal,

Gupta

et al. 2023

Clinical Case Reports

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Primary Hepatic Neuroendocrine Carcinoma: A Rare Entity

Tidwell,

Thakkar,

Nguyen

et al. 2024

ACG Case Rep J

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Neuroendocrine tumors are typically low-malignancy growths arising from neuroectodermal cells of neural crest origin. Neuroendocrine carcinoma, on the other hand, represents a high-malignancy form of these tumors. While rare in the liver, they often indicate metastasis when present. We present a unique case of incidentally discovered primary hepatic neuroendocrine carcinoma. Initially, the patient's management was based on misleading radiological findings. However, histopathology confirmed the diagnosis, with subsequent imaging ruling out an extrahepatic source. Despite this, the patient opted against surgical intervention, resulting in a fatal outcome. This case underscores the critical importance of prompt diagnosis and intervention to avert adverse outcomes.

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Gastroenteropancreatic neuroendocrine tumors in children and adolescents

Yıldırım,

Koca,

Kebudi

2024

Turk J Pediatr

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Background. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare in children and adolescents. Standard management of these tumors has not been well established due to their rarity in this age group. We aimed to report the clinical and pathological characteristics of patients with this rare disease followed and treated between the years 1993-2022. Materials and methods. The medical records of patients with GEP-NETs were reviewed. Results. Fourteen patients (11 girls, 3 boys) were diagnosed with GEP-NET. The median age was 13 (9-18) years. Tumor localization was the appendix in 12, stomach in one and pancreas in one patient. Mesoappendix invasion was detected in four patients two of whom underwent right hemicolectomy (RHC) and lymph node dissection (LND). Of those, one patient had lymph node involvement. The other two had not further operations. Somatostatin was used in one with pancreatic metastatic disease and the other with gastric disease after surgery. No additional treatment was given in other patients. All patients are under follow-up without evidence of disease at a median follow-up of 85 months (7-226 months). Conclusion. GEP-NETs should be considered in the differential diagnosis of acute appendicitis and in cases with persistent abdominal pain. In children, there is invariably a favorable prognosis, and additional surgical interventions other than simple appendectomies generally do not provide benefits. Mesoappendix invasion may not necessitate RHC and LND.

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Primary Hepatic Neuroendocrine Tumor: A Case Report and Literature Review

Cited by 5 publications

References 17 publications

Primary hepatic functional neuroendocrine tumor in an elderly female: Case report

Primary hepatic functional neuroendocrine tumor in an elderly female: Case report

Primary Hepatic Neuroendocrine Carcinoma: A Rare Entity

Gastroenteropancreatic neuroendocrine tumors in children and adolescents

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