Primary hepatocellular carcinoma (“hepatoid” carcinoma) of the pancreas: a case report and review of the literature

Steen, Shawn; Wolin, Edward M.; Geller, Stephen A.; Colquhoun, Steven D.

doi:10.1002/ccr3.26

Cited by 18 publications

(21 citation statements)

References 29 publications

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“…Ectopic liver (EL) is defined as liver tissue with no connection to orthotopic liver, while accessory liver is defined as heterotopic liver tissue with a connection to orthotopic liver [ 1 – 3 ]. EL is a rare congenital abnormality with the incidence of 0.23% reported in the largest autopsy series and 0.47% reported in the largest laparoscopic series [ 1 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Pure hepatocellular carcinoma originates from an ectopic liver nodule located in the pancreas

Braun

Kuncman

Teresiński³

et al. 2017

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Ectopic liver (EL) is a rare congenital abnormality, which is localised most commonly in the wall of the gallbladder. Histoarchitectural abnormalities, which lead to impaired transfer of blood and bile, as well as well demarcation, are characteristic features of ectopic liver nodules. Both features may explain the discrepancies between hepatocellular carcinoma (HCC) cases originating from ectopic liver in comparison to HCC cases originating from orthotopic liver: the strong propensity of ectopic liver to the development of HCC. The latter feature may be linked to the better treatment prognosis in patients with HCC originating from ectopic liver tissue in comparison to those with HCC within orthotopic liver. In this paper, we discuss these differences based on a unique case of pure HCC, which developed in a small ectopic liver nodule in the pancreas.

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Section: Introductionmentioning

confidence: 99%

Pure hepatocellular carcinoma originates from an ectopic liver nodule located in the pancreas

Braun

Kuncman

Teresiński³

et al. 2017

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“…In prior reviews of cases of hepatoid carcinoma, patients had a mean age of 52.9 years with a slight male predominance (62–63.6%) [8, 14]. Specific tumor histopathologies of hepatoid carcinoma with mixed subtypes (acinar, duct cell, mucin, neuroendocrine, and serous microcystic adenoma) when compared to pure hepatoid carcinoma found better survival and recurrence rates with the pure hepatoid pathology [26, 27].…”

Section: Discussionmentioning

confidence: 99%

“…Eleven patients reviewed by Marchegiani et al [14] had pathology consistent only with hepatoid carcinoma. Mixed histopathologies of hepatoid carcinoma included: neuroendocrine tumors (n = 6) and acinar (n = 1), ductal (n = 4), mucinous (1), and serous microcystic adenoma (n = 1) [8, 14]. …”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of hepatoid carcinoma is mainly histologic, with specimens showing features of abundant eosinophilic cytoplasm, finely granular cytoplasm, and intracytoplasmic hyaline globules, with a cellular morphology similar to hepatocellular carcinoma [8]. There is some question of whether these neoplasms arise from tumor transformation of native cells or ectopic nests of liver tissue, but in the absence of surrounding normal liver tissue, it may be assumed to be part of the malignant transformation process.…”

Section: Introductionmentioning

confidence: 99%

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Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review

Chang

Katariya

Lam-Himlin

et al. 2016

Case Rep Gastroenterol

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Fewer than 25 cases of hepatoid carcinoma of the pancreas have been reported in the literature. We present a case in a 61-year-old male with a remote history of Hodgkin’s lymphoma and gastric neuroendocrine cell hyperplasia. On surveillance endoscopic ultrasound, an 8 × 5 mm cystic lesion was seen in the tail of the pancreas. MRI showed a focal pancreatic duct cut-off with mild ductal dilation. Fine needle aspiration was performed, which was concerning for acinar cell carcinoma. The patient underwent distal pancreatectomy and recovered uneventfully. Final pathology demonstrated a 1.3-cm hepatoid carcinoma of the pancreas, with a final clinicopathological stage of T1N0M0. Next-generation nucleic acid sequencing of the tumor did not suggest a viable adjuvant chemotherapeutic agent, and no adjuvant therapy was administered. The patient has no evidence of disease 6 months following resection. A further characterization and description of the outcomes of these rare tumors is warranted to help guide providers and counsel patients.

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“…Hepatocellular cancer is amongst the commonest causes of cancer mortality worldwide [1] and is the fourth most common cause of death from cancer and rapidly increasing in incidence in the United States [2]. Recurrent, most often unrespectable disease in the hepatic remnant contributes significantly to this inability to achieve long term cure rates for colorectal cancer patients [3].…”

Section: Introductionmentioning

confidence: 99%

Hepatic Radioembolisation of Yttrium-90 Microspheres in Animal Model

Bitarafan-Rajabi¹,

Babazadeh²,

Poorbaygi³

et al. 2015

J Nucl Med Radiat Ther

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Background and Aim: Liver directed therapy utilizing yttrium-90 microspheres represents a recently introduced in situ multidisciplinary cancer therapy that has caught the attention of many physicians faced with the challenges of treating these complex patients. Radioactive particle in capillary liver system were assessed through the in vivo test and the leakage to lung or other organ was defined. The concentration of Y-90 in liver tumor without leakage to the other organ was seen which has the important role in radioactive drug successes by radioimbolization method.

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Primary hepatocellular carcinoma (“hepatoid” carcinoma) of the pancreas: a case report and review of the literature

Cited by 18 publications

References 29 publications

Pure hepatocellular carcinoma originates from an ectopic liver nodule located in the pancreas

Pure hepatocellular carcinoma originates from an ectopic liver nodule located in the pancreas

Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review

Hepatic Radioembolisation of Yttrium-90 Microspheres in Animal Model

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