Primary herpetic gingivostomatitis no longer a disease of childhood?

Katz, Joseph; Marmary, Itchak; Ben-Yehuda, Ariel; Barak, Shiomo; Danon, Yehuda L.

doi:10.1111/j.1600-0528.1991.tb00174.x

Cited by 13 publications

(4 citation statements)

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“…The mean age of the primary clinical disease may have risen in recent decades, possibly on a consequence of improved public health and individual hygiene (40, 59, 68, 74). It has been suggested that adults with PHGS present more often with pharyngotonsillitis (75) and sometimes with pharyngitis (76); but this remains controversial (59, 68).…”

Section: Clinical Associations Of Hsv‐1 Infectionmentioning

confidence: 99%

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Arduino

Porter

2007

J Oral Pathology Medicine

339

256

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Herpes Simplex Virus Type 1 (HSV-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva). The prevalence of HSV-1 infection increases progressively from childhood, the seroprevalence being inversely related to socioeconomic background. Primary HSV-1 infections in children are either asymptomatic or following an incubation period of about 1 week gives rise to mucocutaneous vesicular eruptions. Herpetic gingivostomatitis typically affects the tongue, lips, gingival, buccal mucosa and the hard and soft palate. Most primary oro-facial HSV infection is caused by HSV-1, infection by HSV-2 is increasingly common. Recurrent infections, which occur at variable intervals, typically give rise to vesiculo-ulcerative lesions at mucocutaneous junctions particularly the lips (herpes labialis). Recurrent HSV-1 infection within the mouth is uncommon in otherwise healthy patients, although in immunocompromised patients, recurrent infection can be more extensive and/or aggressive. The diagnosis of common herpetic infection can usually be based upon the clinical history and presenting features. Confirmatory laboratory diagnosis is, however, required when patients are, or may be, immunocompromised.

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Section: Clinical Associations Of Hsv‐1 Infectionmentioning

confidence: 99%

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Arduino

Porter

2007

J Oral Pathology Medicine

339

256

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“…Herpetic gingivostomatitis has also been described in adults, with similar clinical manifestations. [1,2] …”

Section: Review Articlementioning

confidence: 98%

Clinical Aspects and Antiviral Therapy in Primary Herpetic Gingivostomatitis

Amir

2001

Paediatric Drugs

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Primary symptomatic herpes simplex virus infection in children usually manifests as gingivostomatitis and is prevalent in the 1- to 3-year age group. The disease involves the buccal and gingival mucosa and the tongue, and lasts approximately 2 weeks. Two recent non-blind studies reported a more rapid regression of symptoms after treatment with aciclovir suspension. Three randomised double-blind, placebo-controlled trials have clearly demonstrated that early aciclovir treatment significantly shortens the duration of all clinical manifestations and infectivity of affected children compared with placebo. We conclude that the treatment of herpetic gingivostomatitis with aciclovir is recommended. Treatment should be started within the first 3 days of disease onset. The proposed therapeutic dose is 15 mg/kg, 5 times daily for 5 to 7 days.

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“…Approximately 30% of pregnant women are seronegative for HSV-1 at the beginning of pregnancy and 2 Á/3% acquire primary HSV-1 infection during pregnancy (2,3). Studies have shown that infection with the HSV type 2 may be associated with maternal foetal transmission in utero (1 in 200,000 pregnancies) (4), leading to a disseminated infection involving multiple organs and a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Primary Herpes simplex Virus Type 1 Gingivostomatitis During the Second and Third Trimester of Pregnancy: Foetal and Pregnancy Outcome

Pardo

Yogev²,

Ben-Haroush³

et al. 2004

Scandinavian Journal of Infectious Diseases

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Primary herpetic gingivostomatitis during pregnancy is a relatively rare phenomenon with no clear management guidelines. We describe 4 cases of primary herpetic gingivostomatitis during pregnancy and review the literature. The diagnosis in all cases was based on clinical manifestations and serology and culture findings. Two of the women received intravenous rehydration. Acyclovir, offered in 2 cases, was refused. Delivery was normal in all 4 cases, with good neonatal outcome, similar to findings in the literature (6 cases). Herpetic gingivostomatitis in the second and third trimester of pregnancy does not appear to be associated with adverse foetal effects. More data are needed to define the risk of this infection during pregnancy.

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Primary herpetic gingivostomatitis no longer a disease of childhood?

Cited by 13 publications

References 1 publication

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features*

Clinical Aspects and Antiviral Therapy in Primary Herpetic Gingivostomatitis

Primary Herpes simplex Virus Type 1 Gingivostomatitis During the Second and Third Trimester of Pregnancy: Foetal and Pregnancy Outcome

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