Primary Hyperaldosteronism

Harvey, Andrea; Refsal, Kent R.

doi:10.1002/9781118997093.ch12

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…14 Signs of hypokalaemia and/ or systemic hypertension are regularly observed with hyperaldosteronism. [14][15][16] In cats, persistent weakness due to hypokalaemic polymyopathy is the most common clinical sign, with severe hypertension reported in up to 85% of cases. 14,15,[17][18][19] Moderate to marked azotaemia and creatine kinase increased activity may also be observed.…”

Section: Discussionmentioning

confidence: 99%

“…[14][15][16] In cats, persistent weakness due to hypokalaemic polymyopathy is the most common clinical sign, with severe hypertension reported in up to 85% of cases. 14,15,[17][18][19] Moderate to marked azotaemia and creatine kinase increased activity may also be observed. 20 The gold standard for diagnosing primary hyperaldosteronism is based on the association of clinical signs consistent with hyperaldosteronism, increased basal plasma aldosterone concentration, decreased plasma renin concentration and visualisation of an adrenal tumour.…”

Section: Discussionmentioning

confidence: 99%

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Long-lasting hypoaldosteronism after adrenalectomy in a cat with hyperaldosteronism

Bouccara,

Dunie-Merigot,

Poujol

et al. 2024

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old neutered male domestic shorthair cat was presented with an abdominal mass, associated renal failure, chronic vomiting, anorexia and progressive polyuria/polydipsia lasting for 3 weeks. Clinical examination and initial blood work revealed azotaemia, hypokalaemia and hypertension. Abdominal ultrasound showed an adrenal mass with a diameter of 3 cm near the right kidney. High serum aldosterone suggested primary hyperaldosteronism. Surgery enabled identification of the mass and its excision along with the right adrenal gland. Histologically, carcinoma of the adrenal cortex was diagnosed. Postoperatively, an increase in serum creatinine and potassium, along with a low serum aldosterone, led to a diagnosis of hypoaldosteronism. Mineralocorticoid therapy for 6 months was necessary, resulting in clinical and biological improvement. Relevance and novel information To our knowledge, this case describes the longest-lasting reported secondary hypoaldosteronism in a cat, after unilateral adrenalectomy for an adrenal carcinoma with hyperaldosteronism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long-lasting hypoaldosteronism after adrenalectomy in a cat with hyperaldosteronism

Bouccara,

Dunie-Merigot,

Poujol

et al. 2024

Journal of Feline Medicine and Surgery Open Reports

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“…28 Elevated serum progesterone levels may contribute to muscle weakness and hypertension seen in these patients. 29 …”

Section: Discussionmentioning

confidence: 99%

Aldosterone and progesterone-secreting adrenocortical adenocarcinoma in a cat with a concurrent meningioma

Leshinsky

Beatty

Fawcett³

et al. 2016

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 12-year-old, male neutered domestic shorthair cat was referred for investigation of suspected hyperaldosteronism due to persistent hypokalaemia, hindlimb ataxia, weakness of 1 month’s duration and a left adrenal mass that was detected on abdominal ultrasound. Neurological examination findings at referral were suggestive of a concurrent left forebrain lesion. Hyperaldosteronism and concurrent hyperprogesteronism were confirmed on endocrine testing. On computed tomography (CT) of the abdomen and thorax there was no evidence of local vascular invasion by the adrenal mass or of metastatic disease. CT and magnetic resonance imaging featured a large, focal rim-enhancing extra-axial left forebrain lesion consistent with a meningioma. Surgical excision of the forebrain mass was followed by adrenalectomy 2 weeks later. The tumours were classified on histopathology as a psammomatous meningioma and an adrenocortical adenocarcinoma, respectively. Immunohistochemical staining of the meningioma confirmed the presence of progesterone receptors. The cat remains well 2 years later.Relevance and novel informationIn humans, elevated serum progesterone levels have been associated with rapid growth of meningiomas due to the presence of progesterone receptors on the tumour. This is the first report of a cat with a progesterone and aldosterone-secreting adrenocortical adenocarcinoma and a concurrent meningioma. Clinicians should be aware of the potential effect of elevated progesterone on meningiomas in cats.

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Feline primary hyperaldosteronism: clinical and surgical approach

Fernández¹,

Seth²,

Murgia³

2016

Companion Animal

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Primary hyperaldosteronism, also known as Conn's syndrome, is probably the most common adrenocortical disease in cats. As in humans, this disease is suspected to be underdiagnosed in cats. Cats presenting with systemic arterial hypertension and/or hypokalaemia are erroneously presumed to have chronic kidney disease, and further investigations are not undertaken. This may potentially exclude a significant number of cats from receiving appropriate treatment. It is therefore important for general practitioners to be aware of the disease. This article describes the pathophysiology, clinical presentation, diagnostic investigations, treatment options and prognosis of feline primary hyperaldosteronism.

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Primary Hyperaldosteronism

Cited by 3 publications

References 15 publications

Long-lasting hypoaldosteronism after adrenalectomy in a cat with hyperaldosteronism

Long-lasting hypoaldosteronism after adrenalectomy in a cat with hyperaldosteronism

Aldosterone and progesterone-secreting adrenocortical adenocarcinoma in a cat with a concurrent meningioma

Feline primary hyperaldosteronism: clinical and surgical approach

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