Primary hyperparathyroidism and laryngeal carcinoma: A cause of associated hypercalcemia

Haar, Jean G.; Boulos, Ekram John

doi:10.1288/00005537-198111000-00018

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Since differentiation was not attempted due to the advanced disease state of these patients, it is possible that some of these were bronchogenic carcinomas. (4). Some of these patients may have had undetected parathyroid adenoma~.~.…”

Section: Discussionmentioning

confidence: 98%

Hypercalcemia in head and neck carcinoma incidence and prognosis

Won

Decker

Drelichman

et al. 1983

Cancer

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A retrospective review of all head and neck cancers seen between January 1, 1975, and September 1, 1981, at Harper‐Grace Hospitals, Detroit, Michigan, was performed. Of 1438 patients with head and neck cancers, 41 (2.9%) had hypercalcemia (calcium > 11.0 mg%) during the course of their disease. The incidence of hypercalcemia by site was 13 of 351 (3.7%) larynx, 7/280 (2.5%) pharynx, 19/733 (2.6%) oral cavity (floor of mouth 4/171, tongue 9/209, tonsil 5/176, palate 1/95, other 0/82, 2/26 (7.7%) nasal cavity, and 0/48 salivary gland carcinomas. Chest radiograph results were positive for mass lesions in 17/35 (49%). Bone scans and/or x‐ray results were positive in 15/31 (48%), negative in 16/31 (52%), and were not evaluated in 10 patients. Of five patients tested, all had inappropriately elevated serum parathyroid hormone (PTH) for their serum calcium level. The hypercalcemia was medically treated in 29/41 (70%), with return‐to‐normal calcium levels in 17/29 (59%). Twelve patients (30%) received only terminal care. Survival from the diagnosis of hypercalcemia ranged from 1 to 514+ days (mean, 80+ days; median 33 days). It is concluded that hypercalcemia is unusual in head and neck carcinoma. Furthermore, hypercalcemia frequently is a late manifestation and terminal event. Finally, hypercalcemia in some patients may be mediated by PTH production. Cancer 52:2261‐2263, 1983.

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Section: Discussionmentioning

confidence: 98%

Hypercalcemia in head and neck carcinoma incidence and prognosis

Won

Decker

Drelichman

et al. 1983

Cancer

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“…Many of these cancer patients had hypercalcaemia in the absence of metastatic disease; the presence of raised parathyroid hormone levels led to evaluation of the parathyroid glands. [9][10][11][12][13] Godsall et al noted primary hyperparathyroidism with concomitant non-parathyroid cancer in 8 of 133 patients with disseminated cancer. The types of cancer included squamous lesions of the head and neck, lung, and colon, breast adenocarcinoma and myeloma.…”

Section: Discussionmentioning

confidence: 99%

“…15 However, there are others who suggest that the occurrence of the two diseases is coincidental rather than due to a shared aetiology. 13 Primary hyperparathyroidism due to parathyroid adenoma has also been reported with a slightly increased frequency in non-aggressive breast cancer patients. 9 10 In our patient, despite the gross impression of a parathyroid adenoma, microscopy of the left superior and inferior parathyroid glands showed hyperplasia with asymmetric enlargement of the left superior parathyroid gland.…”

Section: Discussionmentioning

confidence: 99%