Primary Immunodeficiency Diseases in Adults

Sicherer, Scott H.; Winkelstein, Jerry A.

doi:10.1001/jama.279.1.58

Cited by 39 publications

(18 citation statements)

References 32 publications

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“…CVID [10, 11]is a heterogeneous group of immunological disorders of unknown etiology, characterized by low levels of serum immunoglobulins and impaired antibody responses. Clinical symtoms may develop at any age, usually during the second and third decades of life.…”

Section: Commentmentioning

confidence: 99%

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Nadal¹,

Ferrer²,

Diaz³

et al. 1999

Dermatology

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A 64-year-old man with common variable immunodeficiency developed a persistent papulonodular ulcerative eruption on the right leg. Histopathological examination disclosed a chronic inflammatory infiltrate with central necrosis and palisading granuloma. Repeated microbiological (bacteriological, mycological and mycobacteriological) studies failed to isolate any microorganism. After treatment with intravenous immunoglobulins, a progressive resolution of the skin lesions was observed with a complete clearing after 10 months. Clinicopathological features and therapeutic approaches of sterile granulomatous lesions associated with primary immunodeficiencies are reviewed.

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Section: Commentmentioning

confidence: 99%

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Nadal¹,

Ferrer²,

Diaz³

et al. 1999

Dermatology

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“…These complications can develop in various periods of life but are slightly milder among pediatric patients than in adult cases [51]. Of the aforementioned complications, bronchiectasis subsequent to recurrent pneumonia is more prominent and develops in approximately a third of patients [4,96]. Despite regular and adequate treatment in response to the immune dysregulation that occurs in CVID, affected patients may develop inflammatory diseases, which could result in more pulmonary complications, especially bronchiectasis, in this group of patients [47,97].…”

Section: Management Of Pulmonary Complicationsmentioning

confidence: 99%

A review on guidelines for management and treatment of common variable immunodeficiency

Abolhassani

Sagvand

Shokuhfar

et al. 2013

Expert Review of Clinical Immunology

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“…Certains probiotiques ont été testés dans cette indication avec des résultats divergents en fonction des études [1,19].…”

Section: Traitementunclassified

Diarrhées chroniques infectieuses et dysimmunitaires

Полин

Hagège

2010

Colon Rectum

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Parmi les diarrhées chroniques, certaines sont de mécanisme infectieux ou dysimmunitaire. L'orientation diagnostique est largement guidée par le terrain sur lequel elles surviennent. Chez le patient infecté pour le VIH, le degré d'immunodépression doit être important pour être responsable d'une diarrhée infectieuse opportuniste. Celleci peut être d'origine parasitaire (cryptosporidies, microsporidies, Isospora belli, giardiase) ou bactérienne (mycobactéries atypiques, tuberculose, Clostridium difficile). Lors d'un déficit immunitaire primitif, la diarrhée chronique peut être la manifestation d'une atrophie villositaire associée ou d'une surinfection chronique. Quel que soit le statut immunitaire du patient, la giardiase peut être responsable d'une diarrhée et d'une malabsorption. Elle doit être systématiquement recherchée. Les antécédents du patient (montage chirurgical, diabète, achlorhydrie, immunodépres-sion, etc.) peuvent également orienter vers une pullulation microbienne intestinale. La maladie de Whipple, bien que très rare, doit être évoquée facilement, car son traitement est simple et prévient une évolution fatale.

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Primary Immunodeficiency Diseases in Adults

Cited by 39 publications

References 32 publications

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

A review on guidelines for management and treatment of common variable immunodeficiency

Diarrhées chroniques infectieuses et dysimmunitaires

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