Primary in situ squamous cell carcinoma of the endometrium, with extensive squamous metaplasia and dysplasia

Does Human Papillomavirus Play a Role in Endometrial Carcinogenesis?

“…If, on the one hand, other investigations demonstrated much higher positive rates, varying from 22 to 64% (4,8,10,11,(13)(14)(15), on the other, the great majority of the studies did not compare the presence of HPV in normal endometrial tissue and endometrial carcinomas (5)(6)(7)(8)(9)(10)(12)(13)(14)(15)(16)(17)(18)(19)(20)27). These conflicting results may be associated with the dissimilarities among the analyzed populations or between the methodologies used, especially between those used to detect HPV-DNA, showing either false-positive or negative results.…”

“…Some authors have previously identified the presence of HPV in the uterine cavity (4-6) varying from 3% (7) to 64% (4,(8)(9)(10)(11)(12)(13)(14)(15), whereas others have not found any presence of the virus (16)(17)(18)(19)(20)(21). As research results are contradictory (7,8,(16)(17)(18)(19)22), this study aimed to evaluate the possible relationship between HPV and endometrial cancer by observing paraffinconserved endometrial tissue blocks by using PCR analysis.…”

“…As research results are contradictory (7,8,(16)(17)(18)(19)22), this study aimed to evaluate the possible relationship between HPV and endometrial cancer by observing paraffinconserved endometrial tissue blocks by using PCR analysis.…”

Squamous intraepithelial lesions and squamous cell carcinomas detected by endometrial sampling: Pap test correlation and outcome data

“…[1][2][3][4][5][6] By definition, primary SCC of the endometrium cannot have co-existing primary endometrial adenocarcinoma, connection with cervical squamous epithelium, or co-existing primary cervical SCC. [1][2][3][4][5][6] Primary endometrial SCC may arise in association with squamous metaplasia and dysplasia in the setting of pyometria 7,8 or ichthyosis uteri. [9][10][11] Rare cases of verrucous carcinoma of the endometrium have been also reported.…”

Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium

“…Several pathogenetic factors, such as chronic endometritis, hypovitaminosis A, senile involution of the endometrium with squamous cell metaplasia, and previous irradiation are considered to play a role in the pathogenesis of primary ESCC (Zidi et al 2003 (Im et al 1995) and that hormonal therapy with antiestrogens like tamoxifen is not useful. In addition, treatment with herceptine, as indicated in HER-2/neu positive breast cancers, cannot be recommended because of the negative immunostaining in the investigated cases.…”