Primary intraosseous squamous cell carcinoma in odontogenic keratocyst: A rare entity

Saxena, Chitrapriya; Aggarwal, Pooja; Wadhwan, Vijay; Bansal, Vishal

doi:10.4103/0973-029x.174615

Cited by 13 publications

(8 citation statements)

References 21 publications

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“…The treatment of choice to such tumors is surgery and/or radiation therapy [1,4]. Thomas that very poor prognosis of two year survival rate was seen in patients having PIOSCC [4], this was in common with the present case where the patient had a recurrence twice and his condition deteriorated after the second recurrence and he passed away a month later.…”

Section: Discussionsupporting

confidence: 83%

“…PIOSCC was described to be a rare finding within jaw bones [1]. Bodner et al conducted a retrospective study of 116 cases of PIOSCC between 1938 and 2010 and reported that only 16 cases of these aroused from OKC [2].…”

Section: Discussionmentioning

confidence: 99%

“…PIOSCC is carcinoma that occurs within jaw bones exclusively is considered a rare condition [1]. It is defined as a squamous cell carcinoma (SCC) arising within jaw bones.…”

Section: Introductionmentioning

confidence: 99%

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Primary Intraosseous Carcinoma Arising on Top of Recurrent Kerato-Cystic Odontogenic Tumor in a Young Male Patient

Mohsen¹,

Elnouaem²,

Mahmoud³

2017

Madridge J Dent Oral Surg

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Introduction: Primary intraosseous squamous cell carcinoma (PIOSCC) is carcinoma that occurs within jaw bones exclusively and is considered a rare condition.The exact percentage of malignant transformation in the wall of odontogenic cysts is yet unknown, It varies between 0.01% and 0.02%. Although the process of changing into malignancy is not fully understood, long standing chronic inflammation was reported to be an initiating factor for this transformation.Case Report: We hereby report a case of recurrent odontogenic keratocyst, (OKC) related to the anterior mandibular region. Panoramic radiograph revealed a large radiolucent area which is partially ill defined in some parts. Histological examination of biopsy revealed malignant transformation with dysplastic changes seen in the epithelial lining and areas of frank invasion. Diagnosis of squamous cell carcinoma on top of odontogenic keratocyst was given. Conclusion:The diagnosis of primary intra osseus carcinoma was given depending on the histological pictures which showed prominent dysplastic changes in the epithelial lining of the cyst together with areas of invasion into the adjacent connective tissue capsule. it was of poor outcome.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Primary Intraosseous Carcinoma Arising on Top of Recurrent Kerato-Cystic Odontogenic Tumor in a Young Male Patient

Mohsen¹,

Elnouaem²,

Mahmoud³

2017

Madridge J Dent Oral Surg

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“…In human medicine, PIOSCC is a rare oral tumor, representing less than 2% of all oral SCCs in people [ 8 – 10 ]. The majority of PIOSCCs arise from other benign odontogenic tumors or cysts, while solid de novo type PIOSCC is extremely rare [ 11 , 12 ]. Although PIOSCC has not yet been described in cats, in the clinical case presented here, the radiographic and microscopic features were very similar to those described for human solid type PIOSCC.…”

Section: Discussionmentioning

confidence: 99%

Solid type primary intraosseous squamous cell carcinoma in a cat

et al. 2018

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BackgroundSquamous cell carcinoma (SCC) is the most common nonodontogenic oral tumor in cats. In the jaw, it usually presents as an ulceroproliferative lesion associated with enlargement of the affected bone.Case presentationThis report describes the case of a cat in which clinical and radiographic findings of a mandibular swelling were suggestive of an aggressive process, but the oral mucosa was unaffected. The results of histopathological and immunohistochemical examination of the samples obtained from the intraosseous lesion were consistent with SCC. The animal was euthanized 5 months after initial presentation as a result of the severe progression of the disease, and no other primary tumors were identified at necropsy.ConclusionsBased on the clinicopathological, microscopic, and immunohistochemical staining features, as well as the absence of a primary tumor at a distant site, we propose that the term, solid type primary intraosseous SCC (PIOSCC), be used to describe this neoplasia, as it shares similar features with human PIOSCC.

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“…The patient was later referred to an Oncology center. Associating the histopathological and imaging features[ 1 2 ] a diagnosis of primary intraosseous SCC (PIOSCC) was made.…”

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confidence: 99%