Primary laryngeal and nasal septal lesions in pemphigus vulgaris

Abstract

Synchronous laryngeal and nasal septal lesions in pemphigus vulgaris are rare. The authors report a case of pemphigus vulgaris in an elderly man who was seen with lesions of the supraglottic larynx and nasal septum. The classic skin changes of pemphigus eventually developed, and the patient responded to daily treatments of 80 mg of prednisone. Steroids and immunosuppressive agents remain the treatment of choice, but a favorable prognosis is still dependent on early diagnosis and institution of therapy.

Pemphigus in the Mediterranean region of Turkey: A study of 148 cases

“…Although they needed only mild doses of steroids to suppress the exacerbations, they never attained complete remission. The observations indicate that mucous membrane involvements other than oral mucosa, especially laryngeal and nasal erosions, are not uncommon in PV 20,21 . Approximately 10% of our patients developed lesions on other mucous membranes, generally associated with oral cavity lesions.…”

“…The observations indicate that mucous membrane involvements other than oral mucosa, especially laryngeal and nasal erosions, are not uncommon in PV. 20,21 Approximately 10% of our patients developed lesions on other mucous membranes, generally associated with oral cavity lesions. However, one patient had developed only laryngeal erosions and ulcers without development of classic skin or oral changes for 14 years.…”

Ear, nose and throat involvement in patients with pemphigus vulgaris: correlation with severity, phenotype and disease activity

“…When inadequately treated, laryngeal and nasal involvement of PV may lead to fibrous bands which result in obstruction of the airways 13 …”

Ear, nose, and throat involvement in Egyptian patients with pemphigus vulgaris: a step towards a better management

“…3 PV most commonly affects the oral mucosa but may involve any area of the stratified squamous epithelium. [8][9][10][11][12][13] This is of particular interest to our medical center, which is a tertiary referral hospital for all of Egypt (population~80 million), 14 especially because we are one of the developing countries with limited resources, and endoscopic examination is a rather expensive procedure that is not easily accessible and might traumatize the patient. [8][9][10][11][12][13] This is of particular interest to our medical center, which is a tertiary referral hospital for all of Egypt (population~80 million), 14 especially because we are one of the developing countries with limited resources, and endoscopic examination is a rather expensive procedure that is not easily accessible and might traumatize the patient.…”

“…4 The frequency of ear, nose, and throat (ENT) involvement in PV has been studied before in several studies 3,[5][6][7] and case reports. [8][9][10][11][12][13] This is of particular interest to our medical center, which is a tertiary referral hospital for all of Egypt (population~80 million), 14 especially because we are one of the developing countries with limited resources, and endoscopic examination is a rather expensive procedure that is not easily accessible and might traumatize the patient.…”