Primary leiomyosarcoma of bone: Clinicopathologic, immunohistochemical, and molecular biologic aspects

Abstract

Clinical follow-up suggests that primary osseous leiomyosarcoma has an aggressive biologic behavior. The immunohistochemical studies are useful tools and suggest that osseous leiomyosarcoma arise from the vascular smooth muscle cells within the bone. The molecular biologic findings of a high rate of genomic instability confirm the hypothesis that this rare entity is of an aggressive nature.

Leiomyosarcoma of Bone Arising in Association with a Bone Infarct

“…Although leiomyosarcoma is an extremely rare primary tumour of bone, over 60 cases have been described in the literature 1,2,4,8,9,[11][12][13][14][15] To our knowledge, this is the first report of a leiomyosarcoma arising in association with a bone infarct. Primary leiomyosarcomas of bone have been reported to occur over a wide age range.…”

Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF

“…The current case was diagnosed as leiomyosarcoma of bone. Leiomyosarcoma of bone is considered to be a very rare malignant tumor [10]; thus, we excluded metastatic leiomyosarcoma, especially from possible uterine leiomyosarcoma. FDG-PET has been reported to be useful for diagnosing uterine tumor.…”

The ‘other’ bone sarcomas

“…Most published studies have described specific types of spindle cell sarcomas of bone and are either case reports or case series limited by sample size, and do not evaluate prognostic factors. 8,[17][18][19][20][21] A paper from the Mayo Clinic reported 225 fibrosarcomas of bone diagnosed over an 85-year period, but only 92 patients with available clinical and follow-up data were analysed. 2 The reported disease-free survival for the whole group at five years was 28%, but increased to 45% for patients diagnosed after 1980.…”