Primary leiomyosarcoma of gallbladder

Abstract

Malignant mesenchymalneoplasms of the gallbladder are extremely rare with only 105 cases of primary gallbladder sarcoma having been described. It has a very aggressive behavior and is usually diagnosed at advanced stages. Therefore, curative surgical management may not be possible. We performed a radical cholecystectomy (S4b + S5 segmentectomy), omentectomy and small bowel resection in a 54-year-old patient with locally invasive leiomyosarcoma of the gallbladder. Further studies are needed to confirm the benefit of aggressive treatment for patients with leiomyosarcoma of the gallbladder.

Primary Leiomyosarcoma of the Gallbladder

“…Thus, our case represents the 5 th case in this series [4,6,7]. However, the definitive diagnosis relies exclusively on histological and immunohistochemical techniques [8,9].…”

“…The differential diagnosis of a solid polypoidal gallbladder mass is wide and includes adenomas, adenocarcinomas, and neoplastic polyps such as cholesterol polyps, inflammatory polyps, and adenomatous hyperplasia [3,5]. The definitive diagnosis relies on both morphological features on H&E staining and immunostains [8,9].…”

“…LMS of the gallbladder has a very poor prognosis with a 5-year survival rate less than 5% [ 2 , 5 , 8 , 9 ]. This is due to the highly malignant nature, rapid progression, and early metastasis [ 5 , 10 ].…”

“…This is due to the highly malignant nature, rapid progression, and early metastasis [ 5 , 10 ]. Almost 75% of all patients have liver involvement at the time of diagnosis [ 2 , 7 – 9 ]. However, our patient did not have any liver invasion or distal metastasis.…”

An extremely rare clinical manifestation of gallbladder cancer presenting with abdominal wall invasion with an erythematous skin break

“…4 There are a few reports of perforation of gallbladder cancer; however, in our case, there was no evidence of gallbladder perforation. 2,6 Erythematous skin break in this case might be caused by marked inflammation in the dermis and subcutis.…”