Primary Leiomyosarcoma of Gallbladder: A Rare Diagnosis

Savlania, Ajay; Behera, Arunanshu; Vaiphei, Kim; Singh, Harjeet; Dhiman, Radha K.; Duseja, Ajay; Chawla, Yogesha

doi:10.1155/2012/287012

Cited by 6 publications

(12 citation statements)

References 8 publications

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“…However, the gallbladder does not have a rich blood supply, and it is a rare site for metastatic disease. 15 Our patient had lived for many years with metastatic leiomyosarcoma prior to the identification of a metastasis in the gall bladder. Several cases of primary leiomyosarcoma of the gallbladder have been reported although this is not a common primary site.…”

Section: Discussionmentioning

confidence: 92%

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The Imaging and Pathological Features of Metastatic Leiomyosarcoma in the Gallbladder

et al. 2016

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Uterine leiomyosarcoma is a rare and aggressive malignancy with poor overall prognosis. There have been few reports of metastatic leiomyosarcoma in the gallbladder. We report a case of a 41-year-old female who underwent total abdominal hysterectomy due to presumed uterine fibroids. The postoperative pathology revealed high-grade pleomorphic leiomyosarcoma, with involvement of the uterine serosal surface. She subsequently underwent exploratory laparotomy, followed by pelvic radiation and chemotherapy. Since initial management she has developed metastatic disease and has been under treatment and surveillance for 11 years. She has undergone multiple surgical procedures and numerous lines of systemic therapy for metastatic leiomyosarcoma, including cholecystectomy for a metastatic lesion in the gallbladder. There have been no previous reports of metastatic leiomyosarcoma in the gallbladder. Despite extensive metastatic disease this patient has had prolonged survival with multi-modality management.

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Section: Discussionmentioning

confidence: 92%

“…Several cases of primary leiomyosarcoma of the gallbladder have been reported although this is not a common primary site. 15-17 …”

Section: Discussionmentioning

confidence: 99%

The Imaging and Pathological Features of Metastatic Leiomyosarcoma in the Gallbladder

et al. 2016

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“…Gallbladder leiomyosarcomas are extremely rare and the estimated frequency is 1.4 per 1000 gallbladder malignancies (2). Our search through PubMed revealed that this case is the 22nd in this series (1,(3)(4)(5)(6).…”

Section: Discussionmentioning

confidence: 99%

“…Biochemically, they showed elevated alkaline phosphatase and bilirubin, or leukocytosis resembling those of acute cholecystitis or gallbladder carcinoma (3,5). Gallstones and chronic inflammatory changes have been suggested as the predisposing factors in pathogenesis of gallbladder leiomyosarcoma, although no proofs exist to date (7).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound and CT Findings of Primary Leiomyosarcoma in the Gallbladder: A Case Report

Lee

Yoon

et al. 2014

J Korean Soc Radiol

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Leiomyosarcoma is a malignant mesenchymal tumor which is composed of cells showing smooth muscle differentiations.Primary leiomyosarcoma of the gallbladder is a rare malignancy with poor prognosis. The imaging findings of gallbladder leiomyosarcoma are rarely reported. We present the ultrasonography (US), computed tomography (CT), and positron emission tomography-computed tomography (PET-CT) imaging findings of a primary leiomyosarcoma on the gallbladder in an 82-year-old male. CASE REPORTAn 82-year-old male was referred to our institution from a local clinic due to an incidentally detected large gallbladder mass. IU/L; total bilirubin, 1.81 mg/dL; direct bilirubin, 0.69 mg/dL).Tumor markers were within the normal limits (alpha-fetoprotein, 1.52 IU/mL; cancer antigen 19-9, 1.82 IU/mL). Abdominal ultrasound showed a large polypoid intraluminal protruding mass, displaying heterogeneous echogenicity and relatively welldefined margins with displaced thick hypoechoic overlying mucosa. Intratumoral vascularity was remarkably increased on color Doppler ultrasonography. In the lumen of the gallbladder,

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“…The differential diagnosis of a solid polypoidal gallbladder mass is wide and includes adenomas, adenocarcinomas, and neoplastic polyps such as cholesterol polyps, inflammatory polyps, and adenomatous hyperplasia [3,5]. The definitive diagnosis relies on both morphological features on H&E staining and immunostains [8,9].…”

Section: Discussionmentioning

confidence: 99%

Primary Leiomyosarcoma of the Gallbladder

Chammout

Ghabally

Masri

et al. 2020

Case Reports in Oncological Medicine

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Leiomyosarcoma (LMS) of the gallbladder is an extremely rare entity. Most reported cases were mistakenly diagnosed preoperatively as cholecystitis with or without cholelithiasis. We believe that our article demonstrates the 5th case of gallbladder LMS that was suspected preoperatively to be malignant rather than cholecystitis, which fortunately led to radical resection of the tumor instead of simple cholecystectomy. However, the definitive diagnosis relies exclusively on histological and immunohistochemical techniques. We present a case of a 62-year-old Caucasian female complaining of signs and symptoms suggestive for cholecystitis. On ultrasonography, the gallbladder appeared enlarged and filled with a necrotic mass; thus, the presence of adenocarcinoma was suspected. Multislice Computerized Tomography (MSCT) demonstrated no distant metastasis. An extensive radical cholecystectomy was performed, and histological techniques confirmed a leiomyosarcoma diagnosis. In addition, adjuvant chemotherapy of doxorubicin and ifosfamide was administrated. The patient was on follow-up for 2 years and is doing well till date. The discrimination of gallbladder sarcoma preoperatively remains a clinical and radiological challenge. Although radical resection of the tumor remains the mainstay of the treatment, we believe that adjuvant chemotherapy should be administrated in such cases. However, further studies are required in this field.

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Primary Leiomyosarcoma of Gallbladder: A Rare Diagnosis

Cited by 6 publications

References 8 publications

The Imaging and Pathological Features of Metastatic Leiomyosarcoma in the Gallbladder

The Imaging and Pathological Features of Metastatic Leiomyosarcoma in the Gallbladder

Ultrasound and CT Findings of Primary Leiomyosarcoma in the Gallbladder: A Case Report

Primary Leiomyosarcoma of the Gallbladder

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