Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review

López-Ruiz, María Elena; Yébenes, Laura; Berjón, Alberto; Hardisson, David

doi:10.1177/1066896916679888

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…The ovarian vein is the eighth most commonly affected vessel in cases of vascular LMS that do not originate from the vena cava [20]. Therefore, LMS originating from the ovarian vein is extremely rare, and we are only aware of 15 reported cases [2, 4–17]. Table 1 summarizes the 15 reported cases and our case.…”

Section: Discussionmentioning

confidence: 96%

“…The inferior vena cava is the most commonly affected vessel, accounting for 60% of all vascular cases [2], followed by the large central veins and the long saphenous veins [2, 3]. The ovarian veins are an extremely rare site of origin of LMS, with only 15 reported cases [2, 4–17]. Therefore, we report our experience with a case of primary LMS originating from the right ovarian vein and review the related literature.…”

Section: Introductionmentioning

confidence: 99%

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Vascular leiomyosarcoma originating from the right ovarian vein: a case report and literature review

Hirano¹,

Okumura²,

Maeda³

et al. 2019

surg case rep

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Background Primary leiomyosarcoma (LMS) of vascular origin is a rare lesion, and patients with LMS of vascular origin have poorer prognoses than patients with LMS of other origins. The inferior vena cava is the most commonly affected vessel and accounts for 60% of all vascular cases. However, LMS originating from the ovarian vein is extremely rare, and we are only aware of 15 reported cases. Therefore, we report our experience with a case of LMS originating from the right ovarian vein and review the related literature. Case presentation A 71-year-old Japanese woman with no symptoms was admitted to our hospital because of abnormal findings in a routine abdominal ultrasonography check-up. Contrast-enhanced computed tomography of the abdomen revealed a well-defined, lobulated solid mass with a diameter of 5.5 cm in the right retroperitoneal space. The mass exhibited relatively low uptake during 18 F-fluorodeoxyglucose positron emission tomography. Based on these findings, the differential diagnosis included a retroperitoneal tumor, such as a desmoid tumor, leiomyoma, LMS, and malignant mesothelioma. Operative findings confirmed that the mass had originated from the right ovarian vessels, and en bloc excision was performed for the mass and the right ovarian vessels. The final pathological diagnosis was LMS originating from the right ovarian vein, and the surgical resection margins were free from tumor cells. After histological findings confirmed the LMS diagnosis, the patient underwent adjuvant radiation therapy and has not exhibited signs of local recurrence or metastasis in the 6 months after surgery. Conclusions We encountered a 71-year-old woman with LMS originating from her right ovarian vein. The prognosis of vascular LMS is generally poor. Therefore, careful follow-up will be required for our patient.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Vascular leiomyosarcoma originating from the right ovarian vein: a case report and literature review

Hirano¹,

Okumura²,

Maeda³

et al. 2019

surg case rep

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“…In total, 19 cases of LOV have been reported (Table 1). [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The ovarian vein extends from the plexus near the ovary and fallopian tube to the renal vein. 23 We assigned the LOV into either the upper or lower regions based on the tumor localization in the ovarian vein above or below the L4 level, given that tumors arising from the lower segment of the ovarian vein are potentially confused with internal reproductive malignancies.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma arising from the ovarian vein as a gynecologic malignancy: Two case reports and a review of the literature

Yokoyama

Goda

Sato

et al. 2022

J of Obstet and Gynaecol

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Leiomyosarcoma arising from the ovarian vein has rarely been reported. Herein, we report two cases from a single institute. Given their direct connections to ovarian vessels, both leiomyosarcomas were initially suspected to be gynecological malignancies. In one case, leiomyosarcoma was discovered incidentally without any clinical symptoms; it had a close connection with the ovarian vein, was removed surgically, and the patient has survived for over 12 years. In another case, bowel obstruction caused by the tumor helped to identify metastatic leiomyosarcoma. Blood flow was supplied by the ovarian artery and grew into the lumen of the ovarian vein without invading adjacent organs. After surgical resection, the patient underwent 18 months of chemotherapy prior to palliative care. We propose that leiomyosarcoma arising from the ovarian vein should be treated as a gynecologic malignancy, especially if it develops in the lower abdomen.

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“…Interestingly, they can also be of extra-ovarian vascular origin. In particular, primary leiomyosarcomas arising from the ovarian vein have been described as aggressive neoplasms [53].…”

Section: Role Of Surgery In Gynaecological Sarcomasmentioning

confidence: 99%

Role of surgery in gynaecological sarcomas

et al. 2019

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Gynaecological sarcomas account for 3-4% of all gynaecological malignancies and have a poorer prognosis compared to gynaecological carcinomas. Pivotal treatment for early-stage uterine sarcoma is represented by total hysterectomy. Whereas oophorectomy provides survival advantage in endometrial stromal sarcoma is still controversial. When the disease is confined to the uterus, systematic pelvic and para-aortic lymphadenectomy is not recommended. Removal of enlarged lymph-nodes is indicated in case of disseminated or recurrent disease, where debulking surgery is considered the standard of care. Fertility sparing surgery for uterine leiomyosarcoma is not supported by strong evidence, whilst available data on fertility sparing treatment for endometrial stromal sarcoma are more promising. For ovarian sarcomas, in the absence of specific data, it is reasonable to adapt recommendations existing for uterine sarcomas, also regarding the role of lymphadenectomy in both early and advanced stage disease. Specific recommendations on cervical sarcomas' surgery are lacking. Existing data on surgical approach vary from radical hysterectomy to fertility-preserving surgery in the form of trachelectomy or wide local excision, however no definite conclusions can be drafted on the recommended surgical approach. For vulval sarcomas, complete surgical excision with at least 2 cm of free margin is considered to be the primary treatment which is associated with good prognosis. The aim of this review is to provide highest quality evidence to guide gynaecologic oncologists throughout surgical management of gynaecological sarcomas.

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Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review

Cited by 9 publications

References 17 publications

Vascular leiomyosarcoma originating from the right ovarian vein: a case report and literature review

Vascular leiomyosarcoma originating from the right ovarian vein: a case report and literature review

Leiomyosarcoma arising from the ovarian vein as a gynecologic malignancy: Two case reports and a review of the literature

Role of surgery in gynaecological sarcomas

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