Primary leiomyosarcoma of the skin

Davidson, Lori L.; Frost, Marc L.; Hanke, C. William; Epinette, Warren W.

doi:10.1016/s0190-9622(89)70322-4

Cited by 41 publications

(4 citation statements)

References 10 publications

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“…The use of wide surgical margins, however, has not been demonstrated to have either a survival benefit or a decrease in the rate of local recurrence when compared to other surgical intervention. Recent literature has demonstrated the successful treatment of both types of superficial leiomyosarcoma with narrow margin excision 8,16 as well as with Mohs micrographic excision 7,11,17–20 . Interestingly, articles examining response to treatment commonly include both cutaneous and subcutaneous leiomyosarcoma subtypes, despite the previously noted differences in biologic behavior 7,11 .…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Leiomyosarcoma: A Tumor of the Head and Neck

et al. 2007

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have indicated no significant interest with commercial supporters. Case ReportA 68-year-old gentleman presented to the Veterans Administration dermatology clinic with a severalweek history of a new growth on the left ear ( Figure 1). The lesion was asymptomatic and the patient denied previous treatment to the area. He was feeling constitutionally well. Physical examination revealed a 1.0-cm pink to brown shiny opalescent crusted nodule on the left ear, spanning the midhelix and antihelix. Adenopathy was not appreciated. The initial clinical differential diagnosis included basal cell carcinoma, amelanotic malignant melanoma, and Merkel cell carcinoma. A deep shave biopsy was performed.Histologic evaluation revealed an atypical spindle cell proliferation with pleomorphic nuclei and scattered atypical mitoses infiltrating the dermis (Figures 2 and 3). Immunohistochemistry showed strong positivity for smooth muscle actin and vimentin. Desmin was focally positive. Pankeratin, S100, and Mart-1 staining were negative.A histologic diagnosis of cutaneous leiomyosarcoma was made. Excision of the primary lesion was performed. Lateral surgical margins extended 5 mm beyond the clinical boundary of the lesion, and the deep margin extended to the posterior aspect of the auricular cartilage. Clear surgical margins were confirmed histologically. A porcine xenograft Figure 1. Clinical photograph.Figure 2. Low-power magnification demonstrates an atypical spindle cell proliferation infiltrating the entire dermis. H&E; original magnification, 4 Â .

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Section: Discussionmentioning

confidence: 99%

Cutaneous Leiomyosarcoma: A Tumor of the Head and Neck

et al. 2007

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“…There are 15 documented cases of excisions of LMS by MMS, including this series, and two documented recurrences overall (Table 3). 4,8–11 A recurrence rate of 13% for MMS compares favorably to that associated with wide excision and has the probable advantage of tissue sparing when compared with excisional margins of 2 to 5.0 cm. Fields and Helwig 3 commented that in their series, that LMSs that were excised widely enough to require skin grafting did not recur.…”

Section: Discussionmentioning

confidence: 99%

“…Only one patient in this series required use of a small full‐thickness skin graft because most of the defect was able to be closed primarily (case 3). MMS has previously been shown to be effective treatment of other spindle cell tumors 4–12 and has emerged as the treatment of choice for DFSP with a recurrence rate of 2% or less and significant tissue sparing 13–18 …”

Section: Discussionmentioning

confidence: 99%

Superficial Leiomyosarcoma Treated With Mohs Micrographic Surgery

Humphreys¹,

Finkelstein²,

Lee³

2004

Dermatol Surg

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“…Zur Tiefe ist die Exzision einschließlich des subkutanen Fettgewebes und der Faszie notwendig [2,3,11]. Im Gegensatz zu den abdominellen, retroperitonealen und von den großen Gefäßen ausgehenden Leiomyosarkomen ist die Prognose der kutanen Leiomyosarkome bei radikalem therapeutischen Vorgehen relativ günstig, wobei die Prognose von der Lokalisation des Primärtumors abhängt.…”

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Die Vakuumversiegelungstechnik

Voigt

Blume‐Peytavi

et al. 2001

Der Hautarzt

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The vacuum sealing technique is a new, simple to use procedure for traumatic and chronic soft tissue defects, burns and soft tissue infections. We used this technique for the first time for temporary closure after the resection of deep infiltrating leiomyosarcoma. Radical excision of the tumor with partial resection of the forearm flexor muscles and safety margin of 3 cm led to a large skin defect (12 x 16 cm). For temporary closure of this defect we used the vacuum sealing technique for 7 days. Because of histologically proven incomplete resection of the tumor, we did a second excision and used the vacuum sealing technique a second time for 7 days. After this time period the granulation of the wound ground was excellent, and we closed the defect by split skin transplantation from the thigh. Bacterial infection or other complications were not seen during use of vacuum sealing technique. The vacuum sealing technique induced optimal local conditions for skin grafting: it facilitated granulation tissue production and maintained a clean wound bed without the necessity of changing wound dressing before skin grafting. This technique is painless and does not impair mobility.

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Primary leiomyosarcoma of the skin

Cited by 41 publications

References 10 publications

Cutaneous Leiomyosarcoma: A Tumor of the Head and Neck

Cutaneous Leiomyosarcoma: A Tumor of the Head and Neck

Superficial Leiomyosarcoma Treated With Mohs Micrographic Surgery

Die Vakuumversiegelungstechnik

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