Primary Leiomyosarcoma of the Sphenoid Sinus

Ramakrishnan, Vijay R.; Said, Sherif; Kingdom, Todd T.

doi:10.1001/archoto.2009.114

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…Other sites include the skin, cervical esophagus, and larynx. Trauma, irradiation, chemotherapy, human immunodeficiency virus (HIV) infection, a history of retinoblastoma, and sunlight exposure have been described as possible contributing factors (5,6,64).…”

Section: Leiomyosarcomamentioning

confidence: 99%

Soft Tissue Tumors of the Head and Neck: Imaging-based Review of the WHO Classification

Razek

Huang²

2011

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The World Health Organization (WHO) system for defining and classifying soft tissue tumors is usually applied to lesions that occur in the trunk and extremities, but it also provides an excellent framework for characterizing nonepithelial extraskeletal tumors of the head and neck. Although nonepithelial extraskeletal tumors are in the minority among head and neck lesions, they are by no means rare. The WHO classification system recognizes nine major types based on histologic differentiation: adipocytic, fibroblastic or myofibroblastic, fibrohistiocytic, smooth muscle, skeletal muscle, vascular, pericytic, and chondro-osseous tumors, as well as soft tissue tumors of uncertain differentiation. Tumors of each histologic type may be further subclassified on the basis of their biologic behavior as benign, intermediate (ie, having malignant potential), or malignant. Imaging plays an important role in the noninvasive diagnosis and characterization of nonepithelial soft tissue tumors of the head and neck, providing clues about tumor grade, composition, extent, and involvement of adjacent structures. Although the imaging characteristics of many such tumors are nonspecific, consideration of the clinical history in concert with the imaging findings may help limit the differential diagnosis or even allow reliable diagnosis of some of these tumors.

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Section: Leiomyosarcomamentioning

confidence: 99%

Soft Tissue Tumors of the Head and Neck: Imaging-based Review of the WHO Classification

Razek

Huang²

2011

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129

108

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“…Approximately, fifty cases of primary sinonasal LMS have been reported so far, but only one case is described where LMS originated in sphenoid sinus. [24] LMS arises most frequently from smooth muscle cells within the walls of blood vessels but may also come from undifferentiated mesenchymal cells. Pathologically, the tumors may range from extremely well differentiated to anaplastic.…”

Section: Discussionmentioning

confidence: 99%

Isolated Sphenoid Sinus Lesions: Experience with a Few Rare Pathologies

Sadashiva

Nandeesh

Shukla

et al. 2017

Journal of Neurosciences in Rural Practice

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Introduction:The sphenoid sinus is often neglected because of its difficult access. The deep position of the sphenoid sinus hinders early diagnosis of pathologies in that location. Delayed diagnosis can cause serious complications due to proximity to many important structures.Objectives:The aim of this study is to demonstrate different pathologies which can affect the sphenoid sinus and elucidate the findings.Methods:Cases of isolated sphenoid sinus lesions encountered in the neurosurgical setting which had rare pathologies are discussed. Pathologies such as Langerhans cell histiocytosis, solitary plasmacytoma, chordoma, pituitary adenoma, leiomyosarcoma, fungal infection, and mucocele which appeared primarily in sphenoid sinus are discussed along with their imaging features and pathological findings.Conclusion:Multitude of different pathologies can occur in sphenoid sinus. Detailed preoperative imaging is very helpful, but transnasal biopsy and histological study are required often for definitive diagnosis. The possible advantages of early diagnosis before spread of pathology for prognosis cannot be overemphasized.

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“…They are extremely rare within the head and neck, where they usually arise in the skin, larynx, cervical oesophagus and sinonasal tract. 3,4 Factors associated with an increased risk of leiomyosarcoma include previous irradiation and immunosuppression (particularly due to human immunodeficiency virus). 9,10 Associations have also been reported with Epstein-Barr virus infection and with a number of syndromes, including retinoblastoma, Gardner's syndrome and Recklinghausen's neurofibromatosis.…”

Section: Discussionmentioning

confidence: 99%

“…Certainly, for low grade tumours, complete surgical resection is considered to be the most effective treatment, although all treatment modalities have shown poor results when the lesion is high grade. 4 Radiotherapy is frequently used as an adjuvant, as chemotherapy is considered to be less effective. 3,16 • Leiomyosarcomas are rare within the head and neck • This is the first reported case in the English language literature of leiomyosarcoma of the tonsil • Leiomyosarcomas of the head and neck have a poor prognosis…”

Section: Discussionmentioning

confidence: 99%