Primary Lymphoma of the Breast

Abstract

Seven patients with lymphoma presenting as a breast mass are described. Four of them fulfilled the criteria for primary lymphoma of the breast, and three had evidence of secondary lymphoma of the breast. Two patients were diagnosed with stage IAE disease, and both did well with local treatment with or without chemotherapy. Two patients were diagnosed with stage IIAE disease; both had distant failure without systemic chemotherapy. Although local treatment is curative in a subset of stage IAE disease, combination chemotherapy followed by local radiation is a safer approach. For stage IIAE disease, combination chemotherapy and local radiation therapy should be considered.

Primary Breast Lymphoma: Results of a Controlled Clinical Trial

“…For many years radiotherapy was considered the treatment of choice [1, 2, 5, 7, 13]. However, no long follow-up is available in most cases and relapse appears to be frequent.…”

“…Varying frequencies have been reported, but in most series it is less than 0.7% of all breast malignancies and less than 1% of all non-Hodgkin’s lymphomas. Clinical presentation and radiological findings do not differ from breast cancer and the diagnosis is based on pathological material [1,2,3,4,5,6,7,8]. Different therapeutic approaches have been considered: surgery, radiotherapy, chemotherapy or well-combined two or three therapeutic modalities.…”

“…Different therapeutic approaches have been considered: surgery, radiotherapy, chemotherapy or well-combined two or three therapeutic modalities. No definite conclusions can be drawn because most reports include different histology, different stage (including advanced or disseminated disease) and different treatments and schedules [1,3,4,5,6, 9]. We began a controlled clinical trial to define the efficacy and toxicity of the most common type of therapeutic options for this type of malignant lymphoma.…”

Fine Needle Aspiration Cytology Diagnosis of Lymphoproliferative Disease of the Breast

“…Primary lymphoma comprises < 0.5% of all malignant breast neoplasms. [11][12][13] The majority of the lesions are B-cell NHL, 14 although occasional reports of T-cell lymphoma 15 and HD 16 have been published. Lymphoma in the breast may present as a diagnostic problem on FNAC due to the difficulty in differentiating high grade lymphoma cells from carcinoma, especially lobular.…”

Diagnosis Error: Carcinoma or Primary Breast Lymphoma? A Case Report and Literature Review

“…This rare situation is especially observed during pregnancy or postpartum, suggesting that tumour growth is influenced by hormonal stimulation. Breast lymphoid cells probably originate in mucosa-associated lymphoid tissue (MALT) [7]. PBL may also originate from lymphatic tissue present within the breast adjacent to ducts and lobules, or from intramammary lymph nodes [8,9].…”