Primary lymphoma of the CNS in an infant with AIDS: imaging findings.

Douek, Philippe; Bertrand, Yves; Tran‐Minh, V. A.; Patet, J. D.; Souillet, G; Philippe, N

doi:10.2214/ajr.156.5.2017929

Cited by 16 publications

(1 citation statement)

References 6 publications

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“…Primary CNS lymphomas account for 4%-40% of the NHL in HIV-infected adults and have also been described in children with AIDS [28,[37][38][39][40]. Although CNS NHLs appear to be more common in patients with low CD4 counts, we and others have treated children with relatively well-preserved immune status who developed a CNS tumor.…”

Section: Non Hodgkin's Lymphoma Presentation and Histologymentioning

confidence: 99%

Cancers in Children Infected With the Human Immunodeficiency Virus

Mueller

1999

The Oncologist

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The AIDS epidemic continues unabated in Africa, Asia, and South America, and since patients survive longer, the number of chronically immunocompromised individuals is increasing in Europe and the United States. The number of children with HIV infection who will ultimately develop a malignancy is not known. Currently, tumors represent about 2% of the AIDS‐defining events in children in the United States, but the incidence might be different in developing countries. The most common tumors in HIV‐infected children are non‐Hodgkin's lymphoma, smooth muscle tumors (leiomyosarcomas), and Kaposi's sarcoma (only in Africa). This article provides an overview of epidemiology and clinical and pathological presentations, as well as preliminary data regarding treatment options in children with HIV‐associated malignancies.

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Section: Non Hodgkin's Lymphoma Presentation and Histologymentioning

confidence: 99%

Cancers in Children Infected With the Human Immunodeficiency Virus

Mueller

1999

The Oncologist

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Non-Hodgkin's lymphoma in four children infected with the human immunodeficiency virus. Association with Epstein-Barr virus and treatment

Nadal¹,

Caduff²,

Frey³

et al. 1994

Cancer

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Background. Reports on lymphoid malignancy and its treatment in children infected with human immunodeficiency virus (HIV) are limited. Methods. Antibodies to Epstein‐Barr virus (EBV) were detected by indirect immunofluorescence. DNA was extracted from peripheral blood lymphocytes or biopsy specimens. Polymerase chain reaction was run using primers for EBV. Reaction products underwent Southern blot analysis to confirm EBV specificity. Tumor clonality was assessed by immunohistochemistry and by Southern blot analysis of immunoglobulin heavy‐chain and T‐cell receptor β‐gene rearrangement. Results. Within 1 year, non‐Hodgkin's lymphoma (NHL) was diagnosed in four children infected with HIV. All four were EBV‐seropositive and had detectable EBV DNA in peripheral blood lymphocytes. The EBV‐linked disorders lymphoid interstitial pneumonia and recurrent parotid enlargement preceded NHL in three and two of the children, respectively. In all four patients, NHL involved at one time the central nervous system (CNS). All three tested NHL tissues were positive for EBV DNA. A 12‐week course of chemotherapy given to two children resulted in rapid tumor regression. One of these children experienced meningeal relapse and died 16 months after diagnosis. The other child, who in addition received local irradiation of the affected eye and who underwent surgical removal of the involved ovaries, has been in continuous remission for 20 months. Conclusions. EBV‐associated NHL may be seen more frequently in pediatric patients with HIV. Treatment protocols taking into account NHL propensity for the CNS in this age group need to be developed.

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Malignant Lymphoma

Adesina¹

2009

Atlas of Pediatric Brain Tumors

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Primary lymphoma of the CNS in an infant with AIDS: imaging findings.

Cited by 16 publications

References 6 publications

Cancers in Children Infected With the Human Immunodeficiency Virus

Cancers in Children Infected With the Human Immunodeficiency Virus

Non-Hodgkin's lymphoma in four children infected with the human immunodeficiency virus. Association with Epstein-Barr virus and treatment

Malignant Lymphoma

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