Primary malignant fibrous histiocytoma (myxofibrosarcoma/pleomorphic sarcoma not otherwise specified) of the breast: clinicopathologic study of 19 cases

Hartel, Paul H; Bratthauer, Gary L.; Hartel, James V.; Fanburg‐Smith, Julie C.

doi:10.1016/j.anndiagpath.2011.05.007

Cited by 35 publications

(37 citation statements)

References 21 publications

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“…Historically, MFH tumors consist of spindle-shaped fibroblastic cells and bizarre mononuclear histiocytic cells arranged in a storiform pattern (8). In other words, MFH has a potential for bilateral differentiation.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of giant secondary malignant fibrous histiocytoma following radiotherapy for nasopharyngeal carcinoma: A case report and literature review

et al. 2014

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Malignant fibrous histiocytoma (MFH) is rare in the chest wall, particularly in patients who have undergone radiotherapy for primary nasopharyngeal cancer. In the present study, a case of MFH of the upper chest wall that appeared four years after initial radiotherapy for squamous cell carcinoma of the nasopharynx is reported. Furthermore, two-step surgical management was successfully performed consisting of i) tumor-reductive excision and ii) limb salvage surgery, including wide resection of the tumor mass, defect reconstruction of the chest wall using left latissimus dorsi myocutaneous flap and dermatoplasty of the flap-supplied region. The progress of the clinical characteristics, the reasons for radiation-induced carcinogenesis, the treatment options and the prognostic factors of MFH are also reviewed. Finally, the importance of prevention and follow-up of this malignancy are highlighted and specific advice is offered.

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Section: Discussionmentioning

confidence: 99%

Surgical management of giant secondary malignant fibrous histiocytoma following radiotherapy for nasopharyngeal carcinoma: A case report and literature review

et al. 2014

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“…44,45 Breast MFH affects middle-aged to elderly females, and less often occurs in elderly males. 44,46,47 On clinical examination, a breast MFH presents as a painless palpable mass that the patient reports appeared over a short time. 44,47 One series of nine patients described the presentation as a painless breast mass in all patients.…”

Section: Myofibroblastomamentioning

confidence: 98%

“…47,49 There is great variability in size, with MFHs in one series reported as ranging from 1.3e15 cm with a mean of 6.3 cm. 46 Palpable axillary lymphadenopathy has been reported and regional lymph node metastases are reported to occur in 12e32% of cases. 45,47 MFHs are sarcomas made of fibroblast-like and histiocyte-like cells mixed with pleomorphic giant and inflammatory cells.…”

Section: Myofibroblastomamentioning

confidence: 99%

“…In a series of 16 patients, one underwent needle biopsy, nine wide local excision, one simple mastectomy, three modified radical mastectomy, one radical mastectomy, and one chemotherapy. 46 The type of surgery may relate to the size of the lesion and invasion of deep structures in the breast. The role of chemotherapy, radiation therapy, and axillary lymph node dissection is uncertain due to lack of controlled trials.…”

Section: Myofibroblastomamentioning

confidence: 99%

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Mesenchymal breast lesions

et al. 2015

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“…A rare tumour, it needs to be distinguished from other spindle cell proliferations such as fibromatosis, low-grade spindle cell metaplastic carcinoma, low-grade myxofibrosarcoma59 and stromal overgrowth of phyllodes tumours.…”

Section: Mesenchymal Lesionsmentioning

confidence: 99%

Myoepithelial and epithelial–myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012

2013

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In the 4th edition of the WHO Classification of Tumours of the Breast, myoepithelial lesions are retitled myoepithelial and epithelial-myoepithelial lesions in order to better reflect the dual participation of luminal and myoepithelial compartments in some key entities. Malignant myoepithelioma, described as a section within the chapter on myoepithelial lesions in the 3rd edition, is recognised in the 4th edition as part of metaplastic carcinoma. Adenomyoepithelioma with malignancy is categorised in terms of the cellular component undergoing malignant transformation. The list of antibodies that can be used for identifying myoepithelial cells is updated. Among mesenchymal lesions, new additions are nodular fasciitis and atypical vascular lesions, while the haemangiopericytoma is removed.

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Primary malignant fibrous histiocytoma (myxofibrosarcoma/pleomorphic sarcoma not otherwise specified) of the breast: clinicopathologic study of 19 cases

Cited by 35 publications

References 21 publications

Surgical management of giant secondary malignant fibrous histiocytoma following radiotherapy for nasopharyngeal carcinoma: A case report and literature review

Surgical management of giant secondary malignant fibrous histiocytoma following radiotherapy for nasopharyngeal carcinoma: A case report and literature review

Mesenchymal breast lesions

Myoepithelial and epithelial–myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012

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