Primary Malignant Fibrous Histiocytoma of the Duodenum

Abstract

Background/Aim: We report on a case of primary malignant fibrous histiocytoma of the duodenum. Methods: Report of a case and review of the literature on the occurrence of this tumor in the alimentary tract. Results: The neoplasm was detected incidentally at the time of diagnostic workup for upper gastrointestinal bleeding. Curative surgery using the Whipple procedure was carried out with uneventful postoperative course; no evidence of liver metastases was detected during intraoperative ultrasonography. The patient died of diffuse metastatic liver disease 2 months after surgical resection. Up-to-date review of the literature has added only 3 cases to those previously reported, including that reported by us. Conclusions: The biological behavior of malignat fibrous histiocytomas is extremely aggressive and mainly conditioned by size and histological grading. The treatment of choice, whenever possible, is based on early and complete surgical excision of the tumor.

Malignant Fibrous Histiocytoma of the Ileum at a Site of Previous Surgery: Report of a Case

“…[1][2][3][4][5][6][7][8] Several authors have discussed a possible promoting role of chronic repair processes in the tumorigenesis of malignant fibrous histiocytomas arising at different sites. [9][10][11][12][13][14][15][16][17] Intestinal malignant fibrous histiocytomas have been found associated with a history of pelvic radiotherapy 7,18 and, in one case, with diverticulitis.…”

Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case

“…It has been described in the lung, 8 kidney, 9,10 liver, 11 stomach, 12 duodenum, 13 pancreas, 14 gallbladder, 15 colon, 16 and anal canal. 17 All reported visceral MFHs are presented as case reports.…”

“…In evaluating the literature, we were able to find ten reports of solitary MFH arising in the small intestine in the English-language literature: two cases in the duodenum, 13,18 five in the jejunum, [19][20][21][22][23] and three in the ileum. 3,4,24 It is difficult to present a meaningful evaluation of the signs, symptoms, diagnosis, therapy, and prognosis with such an uncommon condition.…”

“…The treatment of choice, whenever possible, is an early and complete surgical excision of the tumor. 13,26 Adjuvant chemotherapy or radiation is mainly recommended in those patients in whom there is vascular or lymphatic infiltration. 21 In a retrospective study by Fletcher and coworkers, in evaluating 100 cases of MFH of extremity and trunk the median age was found to be 70 years.…”

Primary Intra-abdominal Malignant Fibrous Histiocytoma: A Highly Aggressive Tumor

“…Early detection and complete surgical excision is the treatment of choice and may offer a genuine benefit to the patient [1,6,7,[13][14][15][16][17].…”