Primary Malignant Fibrous Histiocytoma of the Spleen and Liver

Čolović, Nataša; Cemerikic-Martinovic, Vesna; Colović, R; Zogović, S

doi:10.1385/mo:18:4:293

Cited by 15 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The accurate diagnosis of MFH depends on an accurate differential diagnosis from other sarcomas, observing karyomorphism and differential figures, and immunohistological staining. [1,6,7] In our case, we could not get a definite preoperative diagnosis of the splenic tumor according to the physical examination and CT. The final diagnosis was confirmed by the results of the histopathology and immunohistochemistry.…”

Section: Discussionmentioning

confidence: 71%

“…These tumor cells consist of histiocyte-like and fibroblast-like cells with multinucleated giant cells. [6,7] There are positive stainings for lysozyme, vimentin, CD68, and alfa-1 antitrypsin. [6,8,9] MFH has been categorized into five types, based on the histopathologic subtype, including storiform-pleomorphic, myxoid, inflammatory, giant cell and angiomatoid variants.…”

Section: Discussionmentioning

confidence: 99%

“…[6,7] There are positive stainings for lysozyme, vimentin, CD68, and alfa-1 antitrypsin. [6,8,9] MFH has been categorized into five types, based on the histopathologic subtype, including storiform-pleomorphic, myxoid, inflammatory, giant cell and angiomatoid variants. However, only the subtypes of storiform, pleomorphic and inflammatory variants have been reported in the MFH of the spleen in the previously reported literature.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant fibrous histiocytoma of the spleen: An extremely rare entity

2012

View full text Add to dashboard Cite

Primary malignant fibrous histiocytoma (MFH) of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT) scan was performed and a diagnosis of splenic hydatid cyst was made. Splenectomy was done. On histopathological examination, a diagnosis of malignant mesenchymal tumor, possibly storiform variant of malignant fibrous histiocytoma, was made. On immunohistochemistry, the tumor was positive for vimentin and CD68. The post operative period was uneventful. Compared with the twelve previously cases of MFH of the spleen, our patient is the youngest case reported so far.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant fibrous histiocytoma of the spleen: An extremely rare entity

2012

View full text Add to dashboard Cite

show abstract

“…Although a specific antibody for UPS has not been identified, vimentin, CD68, α-SMA and α-antichymotorypsin were often positive in the previous studies (Table 1) . [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Immunohistochemistry may be useful for ruling out specific known lines of differentiation. Splenectomy is the most radical therapy.…”

Section: Discussionmentioning

confidence: 99%

Long-term disease-free survival of an undifferentiated pleomorphic sarcoma of the spleen: A case report and literature review

et al. 2022

View full text Add to dashboard Cite

Introduction: Undifferentiated pleomorphic sarcoma (UPS) primarily occurs in the soft tissues of the extremities, trunk, and retroperitoneum. As the primary UPS of the spleen (splenic UPS) is extremely rare, to the best of our knowledge, only 19 cases have been reported in English literature. No cases of long-term survival without a local or distant recurrence have been reported. Patient concerns: We report the case of a 37-year-old man who was referred to our hospital for a splenic tumor. He had no past medical or relevant familial history. On abdominal computed tomography (CT), a low attenuation solid mass and cystic component with mural calcifications were present at the lower pole of his spleen. The fluorodeoxyglucose-positron emission tomography (CT) indicated it as malignant tumor of the spleen. Diagnoses: The patient’s provisional diagnosis was deduced to be angiosarcoma, which was the most common malignant tumor of the spleen. Interventions: An elective laparoscopic splenectomy was performed, and the histology of the tumor was consistent with UPS (pT1, pN0, cM0, and AJCC8th). No adjuvant therapy was administered. Outcomes: Ten years have passed since the patient’s splenectomy, and he continues to do well, without evidence of local or distant recurrence. Lessons: To the best of our knowledge, this is the first case of long-term recurrence-free survival after surgical management of a splenic UPS. It is probable that radical splenectomy during the disease played the most important role in the patient’s long-term survival. Understanding the characteristic findings of a splenic UPS in an abdominal CT may help to diagnose properly.

show abstract

“…Among the 12 patients of splenic MFH reported [1][2][3][4][5][6][7][8][9][10], including our own one, four were females and eight were males. They ranged from 35 to 82 years old (mean age 53.9).…”

Section: Discussionmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of spleen with spontaneous rupture: a case report and literature review

Zhang

et al. 2010

Med Oncol

View full text Add to dashboard Cite

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma that mainly occurs in the lower and upper extremities, trunk and retroperitoneum. However, primary MFH of the spleen is especially rare. Only 11 cases of splenic MFH have been reported in the English literature. In this report, we describe a 35-year-old man who was found to have a large accumulation of free fluid in the abdominal cavity and a tumor mass 6 cm in diameter with rupture within the spleen by the abdominal ultrasonography. A splenectomy was performed and the histological diagnosis was malignant fibrous histiocytoma. The patient died 7 months after the operation as a result of generalized metastasis. Compared with the 11 previously documented patients of splenic MFH, our patient is the youngest and the first case with spontaneous rupture, which makes our case exceedingly rare. A literature review of primary MFH of spleen is also provided.

show abstract

Primary Malignant Fibrous Histiocytoma of the Spleen and Liver

Cited by 15 publications

References 8 publications

Malignant fibrous histiocytoma of the spleen: An extremely rare entity

Malignant fibrous histiocytoma of the spleen: An extremely rare entity

Long-term disease-free survival of an undifferentiated pleomorphic sarcoma of the spleen: A case report and literature review

Primary malignant fibrous histiocytoma of spleen with spontaneous rupture: a case report and literature review

Contact Info

Product

Resources

About