Primary malignant melanoma of the vagina Poor response to radical surgery and adjuvant therapy

Moros, María Lapresta; Ferrer, Fernando Puig; Mitchell, Maria José Rios; Romeo, Javier; Lacruz, Ramón Lanzón

doi:10.1016/j.ejogrb.2003.06.014

Cited by 11 publications

(7 citation statements)

References 5 publications

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“…8 It may occur at any age but is mainly a disease of postmenopausal women with 75% of patients being 50 and older. 6,7,8 The most common presenting symptom is vaginal bleeding, followed by vaginal mass. 4,6 Grossly, the tumor is polypoid to nodular in the majority of cases.…”

Section: Discussionmentioning

confidence: 99%

“…It has a poor prognosis associated with a high rate of recurrences and rare long-term survival. 7 The prognosis is poor with a five year survival rate ranging from 5 -25%. 2 It appears to be influenced by tumor size with lesions greater than 3 cm having a worse…”

Section: Discussionmentioning

confidence: 99%

“…3 Its clinical behavior is notoriously more aggressive than that of cutaneous and vulvar melanoma with a 5-year survival rate ranging from 5% to 25%. 2,4,6,7 Tumor size is the strongest predictor of survival, whereas tumor thickness is a weak predictor of survival. 2…”

Section: Introductionmentioning

confidence: 99%

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Primary Malignant Melanoma of Vagina – A Case Report with Review of Literature

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Malignant Melanoma of Vagina – A Case Report with Review of Literature

et al. 2007

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“…It accounts for less than 3% of all vaginal malignancies and for 0.3-0.8% of all malignant melanomas [17].…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma of the Female Genital Tract: Unusual Localization

Errarhay¹,

Mamouni²,

Mahmoud³

et al. 2013

JCR

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Abstract:Introduction: Malignant melanoma, which has a highly malignant potential, is a tumor of the skin and mucosal membranes. Malignant melanomas of the female genital tract, including the vulva and vagina, are rare. Their overall prognosis is poor and is worse than that for cutaneous melanomas. Cases presentation: Clinical data for 3 patients with primary malignant melanoma are presented. Diagnosis was based on histologic and immunohistochemical examinations. Case 1 was a 45 year-old women with cervical polyp and excision revealed malignant melanoma. Case 2 was 46-year-old woman with cervical and vaginal melanoma and the third was a 64 year-old women with lentiginous melanoma of the clitoris. One patient was treated with surgery and adjuvant chemotherapy, and two patients received systemic chemotherapy. Conclusion: Although malignant melanoma of the female genital tract is uncommon, literature review shows that prognosis is poor than at other sites, most probably due to more advanced disease at diagnosis. This presentation highlights that early diagnosis by physicians at this relatively rare site is of crucial importance since it may result in improved outcome, similar to that of melanoma at more common sites.

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“…Die Melanome sind normalerweise pigmentiert, nur 10% der Fälle sind amelanotisch [10] . [16] beschrieben, wo ein Melanom der Vagina bei der Erstuntersuchung 1,5 ! 1,0 cm und bei der Untersuchung 25 Tage später 3,5 cm !…”

Section: Diskussionunclassified

Primäres malignes Melanom der Vagina – Fallbericht und Literaturübersicht

Betschart

Orelli

Mihic

et al. 2007

Gynäkol Geburtshilfliche Rundsch

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Das primäre maligne Melanom der Vagina ist ein sehr seltenes Malignom mit weltweit weniger als 300 publizierten Fällen. Noch viel seltener sind Melanommetastasen in der Vagina mit bis anhin 5 beschriebenen Fällen. Bei der von uns beschriebenen Patientin zeigte sich ein von der linken Vaginalwand ausgehendes, 6 cm im Durchmesser messendes und 2,5 cm tiefes Melanom der Vagina ohne lokoregionäre Lymphknoten- oder Fernmetastasen in der Bildgebung. In der Literatur werden als Erfolg versprechendste Therapiemodalitäten die «wide local excision» mit adjuvanter Radiotherapie und die Radikaloperation mit adjuvanter Radiotherapie diskutiert, die ähnliche 5-Jahres-Überlebensraten zeigen. Zur Reduktion des doch erheblichen Risikos der Fernmetastasierung war als weiterführende systemische Therapie eine Immunmodulation mit Interferon-α_2b vorgesehen, welche bei fortgeschrittenen Melanomen der Haut etabliert ist. Leider lag bei der Planung der Interferontherapie 6 Monate nach Diagnosestellung im PET-CT eine ausgedehnte Metastasierung vor, so dass anstelle der Interferontherapie eine palliative Chemotherapie mit Dacarbazine und Thalidomid durchgeführt wurde.

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Primary malignant melanoma of the vagina Poor response to radical surgery and adjuvant therapy

Cited by 11 publications

References 5 publications

Primary Malignant Melanoma of Vagina – A Case Report with Review of Literature

Primary Malignant Melanoma of Vagina – A Case Report with Review of Literature

Primary Malignant Melanoma of the Female Genital Tract: Unusual Localization

Primäres malignes Melanom der Vagina – Fallbericht und Literaturübersicht

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