Primary malignant non-Hodgkin’s lymphoma of the breast: a study of seven cases and literature review

Abstract

Introduction Primary breast lymphoma is an uncommon disease with poor clinical outcome. Breast lymphomas present less than 0.5% of malignant breast neoplasms and 2.2% of extranodal lymphomas. This study investigated the clinicopathological features and optimal treatment of PBL. Case presentations Clinical records of seven Moroccan PBL patients, treated at the National Institute of Oncology, Rabat, Morocco, from 2002 to 2010, were reviewed. Six of the patients were women and one a man, with ages ranging from 32 to 76. Five patients had stage IE and two stage IIE. All of the patients were classified with DLBCL. Of seven patients, one received a mastectomy and three excision of the breast lesion. Axillary dissection was performed in three patients. Two patients received chemotherapy followed by radiotherapy, while four received chemotherapy alone. Complete remission (CR) following primary treatment for all patients with PBL except in two cases was obtained. In one patient, recurrence occurred. Conclusions There is no consensus on the question of how to best treat PBL: Mastectomy offers no benefit in the treatment of PBL. The combined therapy approach, with chemotherapy and radiotherapy, is the most successful treatment. PBL is poorly represented in rituximab-containing trials in DLBCL patients; there is not much experience with this agent in breast DLBCL. Because of the high incidence of central nervous system (CNS) involvement in PBL patients, many authors strongly believe that patients with aggressive forms of PBL should receive CNS infiltration prophylaxis.

Diffuse Large B Cell Lymphoma in a Male Breast - A Rare Case Report

“…Treatment modalities includes surgery, radiotherapy and chemotherapy used alone or in combination (3). Although all histological types of lymphoma have been described, PBLs are commonly B cell lymphomas; approximately one-half are diffuse large B cell lymphoma (DLBCL) (4). There is insufficient information regarding PBL and especially DLBCL of breast in male patients.…”

Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study

“…Excluded from this presentation are malignant lymphoid and hematopoietic tumours such as non-Hodgkin’s lymphomas, myelomas and granulocytic sarcomas, which have been rarely reported in the literature [3,4]. Sarcomas are extremely rare in the breast because most of previously diagnosed sarcomas, including some with obvious differentiation such as osteosarcoma or chondrosarcoma, were later proven to be sarcomatoid metaplastic carcinomas (MCs) due to modern immunohistochemical applications [1].…”

Primary Non-Hodgkin Lymphoma of the Breast- A Rare Case Report

“…There is a slight predilection for the right breast, but the explanation for this remains unclear. [8] It presents most commonly as a palpable mass. [9] The following strict criteria must be met for a neoplasm to be charecterized as primary non-Hodgkin lymphoma of breast : (1) an adequate pathologic specimen, (2) close association of mammary tissue and lymphomatous infiltrate, (3) no evidence of disseminated lymphoma at the time of diagnosis, and (4) involvement of ipsilateral axillary nodes only if it occurs concomitantly with the primary lesion.…”