Primary Melanoma of the Central Nervous System

Pappenheim, Else.

doi:10.1001/archneur.1962.04210020023003

Cited by 70 publications

(24 citation statements)

References 38 publications

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“…and W.J. above the case described by Pappenheim and Bhattacharji (1962). Whether these pial seedlings represent spread via the CSF from the CNS primary tumour or whether there has been a general eruption of malignant change along the meninges cannot be decided from these cases.…”

Section: Discussionmentioning

confidence: 93%

“…Although there seems to be no pathological reason why malignant melanomas should not metastasize to the spinal cord, such cases have not often been reported in the literature (cf. Pappenheim and Bhattacharji (1962) for references). In one article reviewing the literature on primary malignant melanoma of the spinal cord (Hirano and Carton, 1960) the authors reject five cases because they showed a degree of involvement of the basilar cerebral leptomeninges without actual invasion of the brain parenchyma.…”

Section: Discussionmentioning

confidence: 99%

“…It is not unusual to find references in the literature to malignant melanoma involving the nervous system (Hirano and Carton, 1960;Pappenheim and Bhattacharji, 1962;Gibson et al, 1967;Salm, 1967), but there is confusion about which are primary and which secondary to malignant melanoma elsewhere in part due to analysis of reported cases along with one or two observed cases.…”

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confidence: 99%

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Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings.

Hayward¹

1976

Journal of Neurology, Neurosurgery & Psychiatry

148

109

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SYNOPSIS Twenty-seven cases diagnosed as having malignant melanoma affecting the central nervous system have been studied. In 20 patients the tumours represented secondary spread from elsewhere, but there were six who had a primary melanoma either of the spinal cord, leptomeninges, or brain. Confusion exists in the literature about how to differentiate primary from secondary tumours but this study suggests several clinical factors which may indicate that the lesion is probably a primary one. This method of categorizing the cases is supported by the differences in duration of symptoms and survival times for each group and a simple classification can therefore be proposed.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings.

Hayward¹

1976

Journal of Neurology, Neurosurgery & Psychiatry

148

109

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“…Melanomas of the fifth nerve are even rarer 5,6 . In von Recklinghausen's disease, primary malignant melanomas have been described on the skin as well as in the uvea [19][20][21] , iris 22 and meninges [23][24][25] ; none have been reported to involve the fifth nerve as far as we know.…”

Section: Discussionmentioning

confidence: 99%

Primary melanoma of Meckel's cave: case report

Falavigna

Borba²,

Ferraz

et al. 2004

Arq. Neuro-Psiquiatr.

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-We present a case of trigeminal neuralgia with cranial normal magnetic resonance image (MRI) and computed tomography.The pain was not relieved by carbamazepine and microvascular decompression surgery was done.After two months the pain was similar to the condition before surgery. At this time, MRI showed an expansive lesion in Meckel's cave that was treated with radical resection by extra-dural approach. The pathologic examination revealed a primary melanoma. The follow-up after six months did not show abnormalities.KEY WORDS: primary melanoma, central nervous system, Meckel's cave, carbamazepine.Melanoma primário do cavo de Meckel: relato de caso RESUMO -Apresentamos um caso de neuralgia do trigêmeo com investigação radiológica de ressonância magnética (RM) e tomografia computadorizada apresentando resultado normal.A dor não apresentou alívio com carbamazepina, sendo indicado descompressão microvascular do trigêmio. Passados dois meses, o paciente queixava-se de dor com intensidade similar à do pré-operatório. Nova RM mostrou lesão expansiva no cavo de Meckel, a qual foi tratada cirurgicamente por abordagem extra-dural. O exame anatomopatológico foi compatível com melanoma primário. O seguimento radiológico, após seis meses da cirurgia, não apresentou anormalidades.PALAVRAS-CHAVE: melanoma primário, sistema nervoso central, cavo de Meckel, carbamazepina.The central nervous system (CNS) is host to a wide variety of melanocytic neoplasms including the common metastatic malignant melanoma and the relatively benign, as well as overtly malignant, primary neoplasms of leptomeningeal melanocyte 1 . Metastases of malignant melanomas in the CNS are fairly common; their incidence is approximately 5-10% of all tumors metastatizing to the CNS. In contrast, primary melanomas of the CNS are a rare occurrence 2,3 .Trigeminal neuralgia is often the first complaint for a tumor of the Gasserian ganglion. Tumors of the fifth nerve in general are extremely rare and comprise 0.2 % of all primary and secondary intracranial neoplasms 4 . Melanomas of the fifth nerve are even rarer 5,6 . We report a case of trigeminal neuralgia that was not relieved by carbamazepine and microvascular decompression. The expansive lesion was detected in Meckel´s cave only after a second magnetic resonance image (MRI) and the histopathological examination showed a primary melanoma. CASEA 55-year old man, smoker, complains of right trigeminal neuralgia that began 4 months ago. The neurological examination was normal and treatment was instituted with carbamazepine 600mg a day.The neurological investigation was performed by cranial MRI and computed tomography (CT).After 30 days the patient returned without relief of the facial pain and with a normal neuroradiological examination (Fig. 1A). Microvascular decompression was indicated with displacement of the vessel impinging on nerve. The pain relief was temporary. After 60 days the pain was similar to the conditions before surgery and carbamazepine dose was increased to 1000 mg a day CT showed only t...

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“…3 Another theory proposes that, during embryogenesis, a few neuroectodermal rest cells migrate to reside within the neural tube and its coverings. 8 In this way, melanoblasts can reach the nervous parenchyma and may be the origin of the rare cases of primary melanoma of the brain or spinal cord. In our case, a relation to meninges was not found and this fact suggests that the tumor originated from perivascular melanoblasts or from free melanoblasts within the nervous tissue.…”

Section: Discussionmentioning

confidence: 99%

Primary intraparenchymatous spinal cord melanoma

Vaquero

Pedrosa

1998

Spinal Cord

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A case of primary melanoma arising from the spinal cord parenchyma at the Th 10-11 level, in a 50-year-old female, is presented. In this patient, Magnetic Resonance Imaging (MRI) showed an intraparenchymatous lesion, with rounded borders, and an associated intramedullary cyst. On the basis of these ®ndings and the long duration of symptoms, an erroneous preoperative diagnosis of intramedullary ependymoma was made.

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Primary Melanoma of the Central Nervous System

Cited by 70 publications

References 38 publications

Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings.

Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings.

Primary melanoma of Meckel's cave: case report

Primary intraparenchymatous spinal cord melanoma

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