Primary mesenchymal tumors of the colon: A report of three cases

Abstract

Primary mesenchymal tumors of the colon are extremely rare tumors among soft tissue sarcomas. These tumors are more aggressive and have poorer prognosis than adenocarcinoma of the colon. Here, we presented 3 cases of primary mesenchymal tumors of the colon. Their histopathological diagnoses are leiomyosarcoma, pleomorphic liposarcoma, and desmoplastic small round cell tumor, respectively. The rarity of primary mesenchymal tumors of the colon makes it difficult to approach the treatment and predict the prognosis of these rare tumors.

A pooled analysis of risk factors of surgically treated leiomyosarcoma of the colon in adults

“…Adjuvant chemotherapy has been described in only two studies, with mixed results. Yaren A et al [20] reported that a 66-year-old female with CLMS underwent adjuvant chemotherapy with ifosfamide plus doxorubicin after surgery, and no evidence of disease was observed during his follow-up time. Kiran P et al [23] reported that a 54-year old male with LMS of the colon received postoperative chemotherapy with ifosfamide and doxorubicin for six cycles, but then he developed a recurrence after a disease-free period of half a year.…”

Leiomyosarcoma of the colon

“…It was considered that docetaxel, which is so frequently used and effective against both LMS and gastric cancer, could simultaneously reduce the size of these tumors [2]. According to some authors, the most common treatment approach after complete resection is anthracycline-based adjuvant chemotherapy for patients with large tumor size and high-grade tumors [1]. Imatinib mesylate (Gleevec), a 2-phenylaminopyridine that functions as a tyrosine kinase inhibitor, targets the c-kit domain expressed by some GIST.…”

“…Primary mesenchymal tumors of the gastrointestinal tract (GIT) are rarely seen, representing only 0.1%-3% of all gastrointestinal cancers [1]. Leiomyosarcomas (LMS) of GIT are extremely rare mesenchymal neoplasms which account for 0.12% of colon cancers.…”

“…Zaključili smo da multimodalni pristup koji obuhvata hemoterapiju i kompletnu hiruršku resekciju kontroliše lejomiosarkome. Ključne reči: Gastrointestinalni stromalni tumori; Lejomiosarkom; Diferencijalna dijagnoza; Dijagnoza; Imunohistohemija; Morfološki i mikroskopski nalazi; Znaci i simptomi; Kombinovana terapija; Tumor markeri; Aktin; Desmin; Proto-onkogen c-kit mors [1]. Radiotherapy is a less effective treatment in leiomyosarcoma of the gastrointestinal tract.…”

“…Radiotherapy is a less effective treatment in leiomyosarcoma of the gastrointestinal tract. However, it has been reported that leiomyosarcoma can develop after radiotherapy [1].…”