Primary Mucoepidermoid Carcinoma of the Lung with Prominent Clear Cells

Fink, David D.; Lomas, Angela M.; Roden, Anja C.; Shah, Prasun; Zreik, Riyam

doi:10.1080/08998280.2017.11929633

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…The small biopsy collected from our case showed that the tumor cells had undergone infiltrating growth and lacked significant pleomorphism and mitotic activity, indicating a low-grade carcinoma. Most tumor cells had light eosinophilic cytoplasm, and a small number of clear cells prompted us to consider several types of salivary gland-type tumors: low-grade mucoepidermoid carcinoma with clear cells [ 13 ], myoepithelial tumor [ 14 ], HCCC [ 4 ], metastatic clear cell renal cell carcinoma, or non-small-cell lung carcinoma. Immunohistochemistry result showed that the tumor cells were only positive for CK7, p40, ck5/6, and p63, which excluded metastatic clear cell renal cell carcinoma and lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy

Zhang¹,

Han

Zhou

et al. 2022

Diagn Pathol

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Introduction Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors. They most commonly involve the minor salivary glands of the head and neck. HCCC that occurs in uncommon locations and examining samples from small biopsy pose a diagnostic challenge for most pathologists. Case presentation We herein report a primary pulmonary HCCC diagnosed by small biopsy and summarize its histologic, immunophenotypic, and molecular features along with a review of 11 previously reported cases to emphasize the potential diagnostic pitfalls. Conclusions Small biopsy diagnosis of primary pulmonary HCCC is challenging. A collection of mimics needed to be ruled out. Awareness of the key morphologic features of pulmonary HCCC combined with essential immunohistochemistry and molecular tests contributes to the correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy

Zhang¹,

Han

Zhou

et al. 2022

Diagn Pathol

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“…Typical immunoprofile of MEC shows strong nuclear reaction for p63 in the epidermoid and intermediate cells [22]. CK5/6 is also positive in epidermoid cells [3].…”

Section: Discussionmentioning

confidence: 98%

“…Less commonly, MEC presents with pain, facial numbness, paralysis, or respiratory symptoms such as dyspnea, cough, chest pain, and mucopurulent expectoration depending on location, size, extension, and compressive effects over underlying nerves. Pulmonary MEC usually present as endobronchial tumors with a polypoid growth, obstructing the bronchial lumen [3,[22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…Intermediate cells are large and polygonal, frequently with a clear cytoplasm found in nests and sheets, and it can be the predominant cell population, imparting a clear look under the microscope [3]. The cystic spaces are characteristic of low-to intermediate-grade neoplasms, often containing mucin with occasional papillary projections [3,22]. Epidermoid cells form nests or can present as scattered polygonal cells.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic mucoepidermoid carcinoma to the pleura: a case report

Mashiana

Duarte

2022

J Med Case Reports

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Background Mucoepidermoid carcinoma is the most common malignant neoplasm arising from the salivary glands (Ali et al. in J Ayub Med Coll Abbottabad 20(2): 141-2, 2008, Xi et al. in World J Surg Oncol 10: 232, 2012). When arising from anatomic sites other than the salivary glands it can be a diagnostic challenge. Primary and metastatic mucoepidermoid carcinoma from and to the pleura are extremely rare entities that are frequently misdiagnosed as adenocarcinoma, adenosquamous carcinoma, or squamous cell carcinoma (Xi et al. in World J Surg Oncol 10: 232, 2012). Case presentation We describe an unusual case of a 64-year-old Caucasian female patient with metastatic high-grade mucoepidermoid carcinoma to the pleura, morphologically resembling squamous cell carcinoma. Molecular studies of both the parotid gland and pleural tumors helped prove the metastatic nature of the pleural lesion. Conclusions Metastatic mucoepidermoid carcinoma to the pleura is a rare entity, frequently misdiagnosed as squamous cell carcinoma. Differentiating between a lung primary and a metastatic disease has treatment implications and prognostic significance for the patient. When morphologic and immunophenotypic overlap exists, molecular testing can help distinguish mucoepidermoid carcinoma from other neoplasms.

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“…The small biopsy collected from our case showed that the tumour cells had undergone in ltrating growth and lacked signi cant pleomorphism and mitotic activity, indicating a low-grade carcinoma. Most tumour cells had light eosinophilic cytoplasm, and a small number of clear cells prompted us to consider several types of salivary gland-type tumours: low-grade mucoepidermoid carcinoma with clear cells [13], myoepithelial tumor [14], HCCC [4] and metastatic clear cell renal cell carcinoma or non-small-cell lung carcinoma. Immunohistochemistry result showed that the tumour cells were only positive for CK7, p40, ck5/6, and p63, which excluded metastatic clear cell renal cell carcinoma and lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary Lung Hyalinizing Clear Cell Carcinoma: A Diagnostic Challenge in Biopsy

Zhang¹,

Wen

Zhou

et al. 2021

Preprint

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Introduction: Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumours. They most commonly involve the minor salivary glands of the head and neck. HCCC that occurs in uncommon locations and examining samples from small biopsy pose a diagnostic challenge for most pathologists.Case presentation: We herein report a primary pulmonary HCCC diagnosed by small biopsy and summarize its histologic, immunophenotypic, and molecular features along with a review of 11 previously reported cases to emphasize the potential diagnostic pitfalls.Conclusions: Small biopsy diagnosis of primary pulmonary HCCC is fall from ideal. A collection of mimics needed to be ruled out. Awareness of the key morphologic features of pulmonary HCCC combined with essential immunohistochemistry and molecular tests contributes to the correct diagnosis.

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Primary Mucoepidermoid Carcinoma of the Lung with Prominent Clear Cells

Cited by 5 publications

References 16 publications

Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy

Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy

Metastatic mucoepidermoid carcinoma to the pleura: a case report

Primary Lung Hyalinizing Clear Cell Carcinoma: A Diagnostic Challenge in Biopsy

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