Primary mucosa-associated lymphoid tissue lymphoma of the entire esophagus

Musquer, Nicolas; Zidane-Marinnes, Merzouka; Dib, Mamoun

doi:10.1016/j.gie.2017.02.029

Cited by 6 publications

(2 citation statements)

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“…A CR was achieved in a patient treated with cyclophosphamide, vincristine, and prednisone (CVP) therapy (14), while a PR was achieved in a patient treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy (18). Two of the four patients treated with rituximab-combined CHOP (R-CHOP) therapy achieved a CR (15-17, 19). From these results, chemotherapy with and without rituximab might be more effective for achieving a CR.…”

Section: Discussionmentioning

confidence: 99%

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

Takeuchi¹,

Miyahara²,

Morito

et al. 2019

Intern. Med.

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A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.

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Section: Discussionmentioning

confidence: 99%

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

Takeuchi¹,

Miyahara²,

Morito

et al. 2019

Intern. Med.

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show abstract

“…Primary gastrointestinal (GI) lymphoma, especially of the esophagus, is an extremely rare site of involvement, with fewer than 30 cases in the literature [1]. Endoscopic findings are unspecific with varying presentations, including polypoid mass with or without ulceration, varicoid stenosis, strictures, or submucosal nodules, among others [2][3][4]. However, almost no cases involved the entire esophagus.…”

Section: E694mentioning

confidence: 99%

Primary mucosa-associated lymphoid tissue lymphoma of the entire esophagus diagnosed by endoscopic ultrasound-guided fine needle aspiration

Han

Lin

et al. 2022

Endoscopy

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Discovery of Novel Autophagy Inhibitors and Their Sensitization Abilities for Vincristine‐Resistant Esophageal Cancer Cell Line Eca109/VCR

Shan

Hui

et al. 2020

ChemMedChem

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Resistance phenomena, especially acquired drug resistance, have been severely hampering the application of chemotherapeutics during cancer chemotherapy. Autophagy plays a role in maintaining the survival of cancer cells and might mediate resistance to chemotherapy drugs. Herein, a new series of 5‐amino‐2‐ether‐benzamide derivatives were synthesized and evaluated as autophagy inhibitors. Selected from 14 synthesized compounds as lead autophagy inhibitor, N‐(cyclohexylmethyl)‐5‐(((cyclohexylmethyl)amino)methyl)‐2‐((4‐(trifluoromethyl)benzyl)oxy)benzamide (4 d) showed the most obvious effect of LC3B protein conversion. Further, its autophagy inhibition, evaluated by using transmission electron microscopy and confocal microscopy, showed that the fusion of autophagosomes and lysosomes in the final stage of autophagic flux was suppressed. We also found that 4 d could enhance the chemosensitivity of vincristine in vincristine‐resistant esophageal cancer cell line Eca109/VCR in a synergistic, associative manner. Moreover, a computational study showed that 4 d might bind with p62‐zz to inhibit autophagy. We also found 4 d to be relatively less cytotoxic to normal cells versus cancer cells than the reported p62‐zz inhibitor.

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Primary mucosa-associated lymphoid tissue lymphoma of the entire esophagus

Cited by 6 publications

References 0 publications

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after <i>Helicobacter pylori </i>Eradication Therapy: A Case Report and Discussion of Therapeutic Options

Primary mucosa-associated lymphoid tissue lymphoma of the entire esophagus diagnosed by endoscopic ultrasound-guided fine needle aspiration

Discovery of Novel Autophagy Inhibitors and Their Sensitization Abilities for Vincristine‐Resistant Esophageal Cancer Cell Line Eca109/VCR

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