Primary Myeloid Sarcoma of the Gynecologic Tract: A Report of Two Cases Progressing to Acute Myeloid Leukemia

Hernández, José-Ángel; Navarro, José-Tomás; Rozman, Marı́a; Ribera, Josep‐Marǐa; Rovira, Montserrat; Bosch, María-Alba; Fantova, María-José; Mate, José-Luís; Millá, Fuensanta

doi:10.1080/1042819021000016096

Cited by 23 publications

(7 citation statements)

References 12 publications

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“…There have also been reports of MS invading into the vulva. Although MS of the gynecologic tract is exceedingly rare, it is hypothesized that it may actually be underdiagnosed based on postmortem studies showing frequent gynecologic involvement in women who have died of myeloid leukemia [21,22].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

Kahn

Gordhandas

Chapman‐Davis

et al. 2019

Case Reports in Oncological Medicine

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Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecologic tract is exceedingly rare; however, it is hypothesized that it is likely more prevalent than previously understood given postmortem findings and persistence in preserved ovarian tissue. There is minimal literature surrounding MS and extramedullary relapse with no clear guidelines. This is a case report of a 48-year-old woman with MS involving the uterine corpus, fallopian tubes, and left ovary followed by a literature review. The overall aim is to review data regarding leukemic immune evasion and sanctuary sites in order to raise awareness as this represents an important and underrecognized hematologic malignancy in an often misdiagnosed, underrecognized site.

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Section: Discussionmentioning

confidence: 99%

“…Other studies have described cases with multisite involvement in the gynecologic tract, including one with disease in the cervix, mesosalpinx, 4 Case Reports in Oncological Medicine and ovaries. In addition, cases with disease concurrently involving the gynecologic tract and extragynecologic sites have also been reported [22].…”

Section: Discussionmentioning

confidence: 99%

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

Kahn

Gordhandas

Chapman‐Davis

et al. 2019

Case Reports in Oncological Medicine

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“…Myeloid sarcomas of the female genital tract, though uncommon, have been described previously. [6][7][8] In a series of 11 well-studied cases, the site of involvement was the ovary in seven cases, the vagina in three and the uterine cervix in one. In nine of these 11 cases, the female genital tract was the only site of disease at presentation.…”

Section: Discussionmentioning

confidence: 99%

Therapy-related,mixed-lineage leukaemiatranslocation-positive, monoblastic myeloid sarcoma of the uterus

Pullarkat

Veliz²,

Chang³

et al. 2007

J Clin Pathol

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Myeloid sarcomas are tumour masses of myeloid leukaemic cells at extramedullary sites. These tumours can, on occasion, occur without concurrent or antecedent leukaemia. Myeloid sarcomas have been described at unusual locations including the female genital tract. An unusual case of therapy-related acute myeloid leukaemia (t-AML) presenting as isolated monoblastic myeloid sarcoma of the uterus in a patient who had received adjuvant chemotherapy for breast cancer is presented. Fluorescence in situ hybridisation analysis performed on paraffin-wax-embedded tumour tissue revealed amixed-lineage leukaemia (MLL)gene rearrangement, supporting the association of this malignancy with prior chemotherapy. This case illustrates that t-AML can rarely present as isolated extramedullary tumours, and the detection of specific chromosomal abnormalities in these myeloid sarcomas can be useful for risk assessment and guiding definitive therapy.

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“…When myeloid sarcoma is the first manifestation of AML, the involvement of BM and blood appears after a few months. Theoretically myeloid sarcomas can have any location: skin, orbit, paranasal sinuses, bone, chest wall, breast, gastrointestinal tract, respiratory, genital-urinary, central nervous system, peripheral nervous system or lymph node (Hernández et al, 2002;Liesveld & Lichtman, 2006;Paţiu et al, 2008). Abnormalities involving chromosome 8 are the most common cytogenetic abnormalities in nonleukaemic sarcomas (Tsimberidou et al, 2003).…”

Section: Specific Organ Involvementmentioning

confidence: 99%

Diagnosis of Acute Myeloid Leukaemia

Bacârea¹

2012

Myeloid Leukemia - Clinical Diagnosis and Treatment

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Primary Myeloid Sarcoma of the Gynecologic Tract: A Report of Two Cases Progressing to Acute Myeloid Leukemia

Cited by 23 publications

References 12 publications

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

Therapy-related,mixed-lineage leukaemiatranslocation-positive, monoblastic myeloid sarcoma of the uterus

Diagnosis of Acute Myeloid Leukaemia

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