Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report

Hwang, Dong Won; Song, Hyoun Sook; Choi, Yun Yeon; Kim, Hee Sun; Kim, Young Ah; Chun, Kyoung-Chul

doi:10.1080/01443615.2017.1336756

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…To date, there have been limited reports about primary extrauterine choriocarcinoma. Most of these cases were located in the uterine cervix, 1–3 ovary, 4–6 and fallopian tube 7,8 . Primary choriocarcinoma in a cesarean scar is extremely rare and was first reported in 2014 9 .…”

Section: Introductionmentioning

confidence: 99%

Primary cesarean scar choriocarcinoma: A case series and literature review

Huang

Zhou

et al. 2023

Intl J Gynecology & Obste

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Gestational trophoblastic disease (GTD) includes hydatidiform mole, invasive mole, choriocarcinoma, and placental-site trophoblastic tumor. Choriocarcinoma is a rare variety of GTD and usually arises in the uterine body. To date, there have been limited reports about primary extrauterine choriocarcinoma. Most of these cases were located in the uterine cervix, 1-3 ovary, 4-6 and fallopian tube. 7,8 Primary choriocarcinoma in a cesarean scar is extremely rare and was first reported in 2014. 9 Because its clinical manifestations are similar to those of ectopic pregnancy, cesarean scar choriocarcinoma is easily misdiagnosed as a cesarean scar pregnancy (CSP), which results in delayed treatment or even tumor metastasis. Therefore, early diagnosis and effective treatment remain the key for the successful treatment of cesarean scar choriocarcinoma. Here, we present our experience with the diagnosis and management of two patients with cesarean scar choriocarcinoma. In addition, details of the previous five patients were extracted from databases and analyzed to provide

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Section: Introductionmentioning

confidence: 99%

Primary cesarean scar choriocarcinoma: A case series and literature review

Huang

Zhou

et al. 2023

Intl J Gynecology & Obste

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“…5 The cause of gestational choriocarcinoma is the result of current or previous pregnancy, while non-gestational choriocarcinoma of the uterus, arises from germ cells or transformation of another cancer. 6 The location of the cancer in the female genital tract were reported to be mainly at the uterus cervix 6 and ovary. 5 Heavy menstrual bleeding is a common presentation in primary care practice, with incidence of 9.3 per 1000 person years.…”

Section: Introductionmentioning

confidence: 99%

Non-gestational choriocarcinoma as a cause of heavy menstrual bleeding-potential: Primary care detection

Chat¹,

Draman²,

Yusoff³

et al. 2020

Bangladesh J Med Sci

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Choriocarcinoma is a malignant trophoblastic disease. It can be divided into gestational and non-gestational type. Gestational choriocarcinoma consists of less than 1% of total endometrial malignancy, and usually is diagnosed via histopathological examination preceding a suspected molar pregnancy. In contrast to gestational choriocarcinoma, only a few cases of primary non-gestational choriocarcinoma were reported in literature reviews. The reported locations for primary non-gestational choriocarcinoma were ovarian and uterine cervix. Due to its low incidence, this disease is often overlooked leading, to delayed diagnosis. In primary care practice, heavy menstrual bleeding is a common presentation. Further evaluations, such as full blood count, ultrasound pelvis or hysteroscopy are usually required. We would like to report a case of potentially earlier detection of non-gestational choriocarcinoma in a 52 years old lady who was presented with heavy menstrual bleeding for a duration of one year. Her symptom persisted despite receiving medical treatment in a few local primary care clinics. She was admitted to a tertiary hospital for symptomatic anaemia which required blood transfusion. Further evaluations, (i.e., laboratory tests, ultrasound, Computed Topography (CT) scan, bone scan, hysteroscopy and laparotomy total abdominal hysterectomy and bilateral salphingo-oophorectomy (TAHBSO) and histological examination) concluded a diagnosis of primary non-gestational choriocarcinoma of fundal uterus with lung metastasis. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.755-759

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“…Non‐gestational choriocarcinoma (NGCC) is a choriocarcinoma that does not originate from pregnancy and is categorized as either a germ‐cell tumor or a tumor caused by abnormal differentiation from other cancers. Many cases of NGCC are reports of choriocarcinoma originating from the ovaries, and reports on primary non‐gestational uterine choriocarcinoma are very rare …”

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confidence: 99%

Primary non‐gestational uterine choriocarcinoma mimicking leiomyoma

Sano

Moriya

Suzuki

et al. 2019

Pathology International

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Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non‐gestational in origin. However, primary non‐gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non‐gestational uterine choriocarcinoma. This 46‐year‐old woman had no history of pregnancy. She was referred to our hospital for treatment of the myoma delivery. After tumor removal, histological examination led to the diagnosis of choriocarcinoma. The serum human chorionic gonadotropin level (207,300 mIU/mL) prior to surgery was abnormally high, and because the computed tomography scans additionally revealed lung metastasis, the patient was diagnosed with FIGO stage III choriocarcinoma. Due to the lack of pregnancy history and abstinence from sexual intercourse for >1 year, we performed short tandem repeat analysis, and diagnosed the patient with non‐gestational choriocarcinoma. Despite treatments using multiple anticancer agents after the surgery, the patient died 1 year after starting the treatments. On this occasion, we report a very rare case of a premenopausal woman who was diagnosed with primary non‐gestational uterine choriocarcinoma mimicking leiomayoma.

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Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report

Cited by 7 publications

References 7 publications

Primary cesarean scar choriocarcinoma: A case series and literature review

Primary cesarean scar choriocarcinoma: A case series and literature review

Non-gestational choriocarcinoma as a cause of heavy menstrual bleeding-potential: Primary care detection

Primary non‐gestational uterine choriocarcinoma mimicking leiomyoma

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