Primary non-Hodgkin's lymphoma of the prostate gland: Case report and review of the literature

Bell, C.R.W.; Napier, Mark; Morgan, RJ; Dick, Robert; Jarmulowicz, Michael; Jones, Alison

doi:10.1016/s0936-6555(05)80020-2

Cited by 18 publications

(8 citation statements)

References 12 publications

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“…It often shows diffusely enlarged, non-tender, firm or rubbery consistency and obliteration of the median sulcus when examined by DRE. Though the prostate is hard, it is usually not as hard as the typical prostate carcinoma [5, 6]. The serum acid phosphatase value and PSA in general are usually within the normal range, but Tomaru et al .…”

Section: Discussionmentioning

confidence: 99%

Primary lymphomas of the prostate: two and a review of the literature

Wang¹,

Jiang²,

Li³

2012

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IntroductionNon-Hodgkin lymphoma (NHL) is a common disease, but primary lymphoma of the prostate is rare.Material and methodsHere we present two cases of primary NHL of the prostate and a review of the relevant literature.ResultsBoth of them had no abnormal lymph node or hepatolienal enlargement. The first case underwent prostatic biopsy which indicated that it was NHL. The patient underwent combination chemotherapy three times, then a radical cystoprostatectomy. In the second case, the prostatic biopsy was not helpful for diagnosis. Therefore a radical prostatectomy was performed before the proper chemotherapy been given. He died half a year later because of a cerebrovascular accident.ConclusionsWe think it is difficult to get an accurate early diagnosis when the lymphoma occurs only in the prostate. Even the prostatic biopsy could not provide clear evidence. Early and appropriate treatment can extend the survival time and improve the quality of life.

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Section: Discussionmentioning

confidence: 99%

Primary lymphomas of the prostate: two and a review of the literature

Wang¹,

Jiang²,

Li³

2012

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“…Primary prostatic lymphomas (PPLs) are rare tumours . Criteria for primary involvement have been proposed by Bostwick and Mann, and include symptoms attributable to prostatic enlargement; the prostate as the predominant site of involvement; and the absence of involvement of secondary lymphoid organs (liver, spleen, or lymph nodes).…”

Section: Introductionmentioning

confidence: 99%

“…Criteria for primary involvement have been proposed by Bostwick and Mann, and include symptoms attributable to prostatic enlargement; the prostate as the predominant site of involvement; and the absence of involvement of secondary lymphoid organs (liver, spleen, or lymph nodes). Fewer than 300 cases of prostatic lymphoma have been reported with the largest case series reporting primary and secondary prostatic lymphoma . Clinical symptoms are frequently related to obstructive uropathy, although the latter is not specific …”

Section: Introductionmentioning

confidence: 99%

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Exclusive B‐cell phenotype of primary prostatic lymphomas: a potential role of chronic prostatitis

et al. 2020

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Aims Primary prostatic lymphomas (PPL) is exceedingly rare. The aim of this study was to investigate the largest series of PPL obtained from a nationwide expert pathologist network, and thus try to understand the pathophysiology of these tumours. Methods and results Up to 66 000 lymphoma cases have been collected and submitted for central expert review by the French Lymphopath network. We confirm the low frequency of PPL (n = 77; 0.12%), all cases being of B‐cell origin. Diffuse large B‐cell lymphoma and small lymphocytic lymphoma were the most frequent subtypes, comprising 31% and 26% of cases respectively, followed by mucosa‐associated lymphoid tissue (MALT)/lymphoplasmacytic lymphoma (19%), follicular lymphoma (12%), mantle cell lymphoma (6%), Burkitt lymphoma (4%), and unclassified lymphoma (1%). Clinical data obtained in 25 cases suggests that PPLs are rather indolent tumours. Our hypothesis for B‐cell recruitment in the prostatic tissue was derived from the observation in chronic inflammation (prostatitis) of frequent heterotopic proliferation of high endothelial venules (HEVs). The latter are dedicated to lymphocyte entry into secondary lymphoid organs, here putatively driving circulating clonal B‐lymphocytes from the blood into the inflamed prostate. This may account for the relatively high incidence of small lymphocytic lymphoma consistently reported in series of primary or secondary prostatic lymphoma. As in other organs or glands, chronic inflammation may promote antigen‐dependent intraprostatic MALT lymphoma and diffuse large B‐cell lymphoma development. Conclusions PPLs are exclusively of B‐cell origin, and chronic inflammation resulting from the proliferation of high endothelial venules could play some role in their development.

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“…El linfoma prostá tico primario supone un 0,1% de los linfomas diagnosticados y menos del 0,009% de todas las neoplasias prostá ticas. La afectació n secundaria de la pró stata por un linfoma sisté mico es má s frecuente 9 . Es importante diferenciar el origen de la neoplasia secundaria de pró stata diferenciando la metá stasis de la invasió n por contigüidad.…”

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