Primary oral and nasal transmissible venereal tumor in a mix-breed dog

Abstract

Transmissible venereal tumor (TVT) is a coitally transmitted tumor of dogs with widespread distribution. The present study describes the occurrence of the primary oral and nasal TVT in a 10-year-old, female, mix-breed dog. The case was presented with a history of anorexia, inability to swallow and dyspnea. Clinical examinations revealed the emaciation, muzzle deformity due to the presence of a friable, fleshy, cauliflower-like mass in the oral cavity and submandibular lymphadenopathy. TVT was diagnosed based on histopathological findings. The dog was discharged with therapeutic intervention with vincristine. Unfortunately, the case died before readmission because of the progressive worsening of the general condition. Our findings highlight the need for considering TVT for the differential diagnosis of the extragenital masses in dogs.

Nasal and Ocular Forms of Transmissible Venereal Tumor in Dogs

“…Radiographic deformity and lysis of the facial and nasal bones with the presence of the tumorous lesions in both nasal and oral cavities has been reported in dogs suffering from oral and nasal CTVT (Rezaei et al, 2016). This corroborate to the findings of the present study.…”

“…Clinical signs of CTVT are typical with bleeding from the nearest cavity involved which was also observed in the present cases. Dyspnea was another important clinical sign present in the dogs with nasal cavity involvement as also reported in literature (Rezaei et al, 2016). During her surgery for paracostal hernia, the oro-nasal fistula was also repaired (Fig.…”

“…in various organs but primary extra genital CTVT are sporadic (5.1%) (Milo and Snead, 2014, Rezaei et al, 2016). Metastasis is uncommon (5%); when it occurs, it is usually to the regional lymph nodes including inguinal and external iliac lymph nodes but may also be seen in the kidney, spleen, liver, eye, tonsils, brain, pituitary, skin and subcutis, maxillary bone, mesenteric lymph nodes and peritoneum (Ganguly, 2016).…”

Computer tomographic imaging in 4 dogs with primary nasal canine transmissible venereal tumor and differing cellular phenotype

“…Complete tumoral remission was reached with chemotherapy in all 4 cases. Information regarding the effectiveness of chemotherapy or evolution of nasal CTVT under treatment is extremely limited because the prognosis of nasal CTVT is poor in many cases, and therefore, the dogs are euthanized …”

“…Information regarding the effectiveness of chemotherapy or evolution of nasal CTVT under treatment is extremely limited because the prognosis of nasal CTVT is poor in many cases, and therefore, the dogs are euthanized. 8,16,26 In this series, cases 2, 3, and 4 were treated with vincristine, whereas case 1 was treated with doxorubicin instead of vincristine with the expectation of a faster response considering the severe respiratory signs and plasmacytoid cytological phenotype. Solely on the basis of these reports, it is difficult to make a recommendation for the treatment of CTVT with nasal damage.…”