Primary Orbital Hemangiopericytoma

Henderson, J. Gordon; Farrow, George M.

doi:10.1001/archopht.1978.03910050362013

Cited by 57 publications

(10 citation statements)

References 7 publications

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“…In the present case, no distinct mitotic figures were seen, suggesting little activity of the tumor, which was contrary to the clinical findings of malignancy including invasion into the iris of this neoplasm. Even so, a case histologically diagnosed as a benign hemangiopericytoma resulted in death due to metastatic spread [15]. …”

Section: Discussionmentioning

confidence: 45%

Intraocular Hemangiopericytoma

et al. 2001

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A 55-year-old man presented with a smoothly elevated solid choroidal mass with choroidal detachment in the temporal region of the left eye. Both fluorescein and indocyanine green angiography suggested a vascularized lesion such as an angioma. However, radiographic examination revealed a solid, circumscribed, dome-shaped mass. During a 3-month observation, the mass gradually enlarged and invaded the iris. The possibility of malignant melanoma could not be ruled out. Due to rapid and continued growth of the tumor, the eye was enucleated. Histopathologic examination revealed proliferation of spindle-shaped cells surrounding reticulin-positive vessels, which is characteristic of hemangiopericytoma. To our knowledge, this is only the fourth reported case of intraocular hemangiopericytoma and the first diagnosed in a male patient.

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Section: Discussionmentioning

confidence: 45%

Intraocular Hemangiopericytoma

et al. 2001

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“…It is believed that HPCs arise from pluripotential perivascular mesenchymal cells, and can occur anywhere in the body. The orbit is a rare location for this particular tumor, and corresponds to 0.8% to 3% of all primary orbital tumors 3. HPC generally affects adults (median age 45 years), with an equal sex distribution 4–6.…”

Section: Discussionmentioning

confidence: 99%

Rapid growth of an orbital hemangiopericytoma with atypical histopathological findings

Pacheco

Fernandes

Miyamoto

et al. 2013

OPTH

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Hemangiopericytoma is a rare vascular tumor that originates from pericytes. The orbit is a rare location for this particular tumor, and corresponds to 0.8% to 3% of all primary orbital tumors. We report a case of a hemangiopericytoma in a 45-year-old man that had an unusual presentation, as a rapidly growing mass in the anterior right inferior orbit. Given that there are no clinical or radiological signs pathognomonic of this tumor, a careful histopathological examination is necessary to confirm the diagnosis. In our case, it presented also with unusual histopathological findings. The clinical features, radiological findings, differential diagnosis and treatment of this challenging entity are reviewed in this case report.

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“…Various mesenchymal tumours of both fibrohistiocytic and vascular origin are well-described causes. Hemangiopericytomas (HPC) are rare vascular tumours which can infrequently involve the orbit and their incidence is estimated to be 0.8% to 3% of primary orbital tumours 1,2 . We herein report a new case of orbital HPC revealed by unilateral proptosis in a 38-year-old man.…”

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confidence: 99%

Primary Orbital Hemangiopericytoma: An Unusual Cause of Unilateral Proptosis

Limaiem¹,

Limaïem²,

Kourda³

et al. 2010

Can. j. neurol. sci.

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Painless unilateral proptosis is a frequent manifestation of numerous orbital neoplastic and non neoplastic processes. Various mesenchymal tumours of both fibrohistiocytic and vascular origin are well-described causes. Hemangiopericytomas (HPC) are rare vascular tumours which can infrequently involve the orbit and their incidence is estimated to be 0.8% to 3% of primary orbital tumours 1,2 . We herein report a new case of orbital HPC revealed by unilateral proptosis in a 38-year-old man. Our aim was to highlight the clinicopathological and radiological features of this rare neoplasm with review of the current literature. CASE REPORTA 38-year-old previously healthy man, presented with a onemonth history of rapid expanding intra-orbital mass resulting in painless proptosis of the left eye. On admission, ophthalmologic examination revealed severe left eye proptosis (grade III). A palpable mass in the left orbit was protruding out of the palpebral fissure (Figure 1). It was irreductible, non-tender and nonpulsatile. The conjunctiva was chemotic and there was marked ulcerative keratitis. The visual acuity was 0 / 10 in the affected eye and ocular movements were restricted in all directions. The contralateral eye was within normal limits. Computed tomography (CT) scan of the orbital region (Figure 2) revealed a 87 x 54 x 32 mm, well-circumscribed mass within the intraconal space of the left orbit extending along the optic nerve and homogeneously enhanced after intravenous administration of contrast medium. Magnetic resonance imaging (Figure 3) showed a soft tissue mass iso-intense on T1-weighted images and hypo-intense on T2-weighted images. Laboratory tests and chest radiograph were within normal limits. An incisional biopsy of the intra-orbital mass was performed but was difficult to realize due to excessive haemorrhage. Histological examination of the tiny biopsy specimen obtained, established an initial diagnosis of an undifferentiated sarcoma. Orbital exenteration was carried out due to the infiltrative and highly vascular nature of the tumour.Macroscopically, the exenteration specimen measured 130 x 120 x 105 mm. A small atrophic globe at the anterior aspect of the specimen did not appear invaded by the tumour. The cut section of the mass showed a firm greyish white tumour. The eyelids were not infiltrated by the tumour. Histological examination of the surgical specimen showed a hypercellular neoplasm predominantly composed of randomly oriented polygonal and rounded cells with ill-defined cytoplasm

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Primary Orbital Hemangiopericytoma

Cited by 57 publications

References 7 publications

Intraocular Hemangiopericytoma

Intraocular Hemangiopericytoma

Rapid growth of an orbital hemangiopericytoma with atypical histopathological findings

Primary Orbital Hemangiopericytoma: An Unusual Cause of Unilateral Proptosis

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