Primary Osteosarcoma of the Breast in a Patient Treated Previously for Invasive Ductal Carcinoma: An Unusual Presentation of a Very Rare Primary Breast Malignancy

Abstract

Primary osteogenic sarcoma of the breast is a rare clinical entity with few cases described in the literature. Unfortunately, the prognosis for these patients is poor when compared to invasive carcinomas of the breast. We report a case of a 58-year-old female who developed a primary osteogenic sarcoma of the breast five years after being treated for invasive carcinoma of the ipsilateral breast without the use of radiotherapy.

Primary breast osteosarcoma: A case report and review of the literature

“…Prior history of epithelial breast cancer in the same side or contralateral side has been reported several times. 7 , 8 Some reported cases develop PBOS after irradiation. 9 , 10 In addition, some cases presented with a history of trauma or even a foreign body.…”

“…The previous history of burn has been noted in one case of PBOS 6 but to the best of our knowledge, it has not been reported elsewhere. Prior history of epithelial breast cancer in the same side or contralateral side has been reported several times 7,8 . Some reported cases develop PBOS after irradiation 9,10 .…”

Primary breast osteosarcoma in a patient previously treated for ipsilateral invasive ductal carcinoma: An unusual case report with clinical and genomic features

“…A prior history of burns, trauma, or even a foreign body has been reported in some cases of PBOS ( 1 , 6 ). In addition, some cases presented with a history of epithelial breast cancer on the same side or contralateral side ( 11 , 12 ). Of note, some patients have been reported to have developed PBOS after undergoing radiotherapy ( 13 , 14 ).…”

Primary Breast Osteosarcoma; a case report and review of the literature

“…predisposing and precipitating factors the previous history of burn has been noted in one case of PBOS (6) but to the best of our knowledge, it has not been reported elsewhere. Prior history of epithelial breast cancer in the same side or contralateral side has been reported several times (7,8) . Some reported cases develop PBOS after irradiation (9,10) .…”