Primary Ovarian Neuroblastoma

Muhlstein, J.; Rodriguez-Dahlhoff, Sandra; Marie, Béatrice; Fouyssac, Fanny

doi:10.1016/j.jpag.2010.01.005

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…PNETs are uncommon entities especially for the female genital tract and the ovaries are the most common location ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ) . It seems that the exact age for non-skeletal ES is not clear, but cases in the literature were seen between the second and third decades of the life.…”

Section: Discussionmentioning

confidence: 99%

“…To date, nearly 30 ovarian ES cases have been reported and some of these are summarized in Table 1 . ( 6 , 7 , 8 , 9 , 10 , 11 , 17 , 18 , 19 , 20 , 21 , 22 ) PNETs have poor prognosis and due to the fact that tumors have an aggressive potential, survival periods are short. Two reported cases in literature had six years’ survival.…”

Section: Discussionmentioning

confidence: 99%

“…All these stem from precursors in the neuroectoderm, and they are all called neuroectodermal tumors of the ovary. The translocation between chromosomes 11 and 22-t(11;22) (q24;q12)-is the same genetic problem for the PNETs group ( 8 , 9 , 10 ) . The differential diagnoses of PNETs of the ovary include several primary and metastatic ovarian neoplasms such as juvenile granulosa cell tumors, lymphoblastic lymphoma (LBL), extrauterine endometrial stroll sarcoma, and serous ovarian carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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Primitive neuroectodermal tumor of genital tract in hysterectomized patient: A case report

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et al. 2018

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Primitive neuroectodermal tumors are high-grade malignant neoplasms. These are uncommon entities for the female genital tract. The treatment, management and follow-up period of Ewing’s tumors are not well-defined because of their rarity in the genital tract. Surgical debulking is the mainstay treatment in all cases. After debulking surgery, patients receive chemotherapy and/or radiotherapy and there is a relation between disease stage and survival. Herein, we present a case of ovarian primitive neuroectodermal tumor with a review of previously reported cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primitive neuroectodermal tumor of genital tract in hysterectomized patient: A case report

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et al. 2018

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“…According to Muhlstein et al (2010), in the 9 reported cases, including 4 malignant transformed teratoma cases, 4 patients died 2–7 months after operation, 2 patients relapsed 11 and 24 months after operation, and 3 patients achieved complete remission during the 7- to 24-month follow-up periods (Muhlstein et al, 2010). However, the reported remissions have an insufficient follow-up period, with a maximum of 2 years.…”

Section: Discussionmentioning

confidence: 99%

Two cases of primary ovarian neuroblastoma arising from mature cystic teratomas

Niwa

Yamamuro

Kato

et al. 2013

Gynecologic Oncology Case Reports

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“…Neural tissue occurs with considerable frequency in mature cystic teratoma but the development of a malignant neural neoplasm in an ovarian tumor of this type is an event of exceptional rarity. Only 9 cases with a primary ovarian location have been published in the literature since 1982 [ 4 ]. Natural killer (NK) lymphocytes represent one of the most efficient cellular mechanisms by which the immune system can destroy tumor or virally infected cells [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Primitive Neuroectodermal Tumor in an Ovarian Cystic Teratoma: Natural Killer and Neuroblastoma Cell Analysis

et al. 2014

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In the present study, we report an extremely rare case of a 31-year-old woman with neuroblastoma arising in an ovarian cystic teratoma. We analyzed the expression of activating receptors on natural killer (NK) cells derived from the patient's peripheral blood and peritoneal fluid. In addition, we investigated the presence of specific ligands recognized by different NK cell receptors on tumor cells. We show that NK cells isolated from peritoneal fluid expressed certain triggering receptors including DNAM-1 (CD226) and CD16 with lower intensity as compared to peripheral blood NK cells. Remarkably, at variance with most cases of childhood neuroblastoma, the tumor cells from this patient expressed substantial amounts of HLA class-I molecules. These molecules are known to be protective against NK cell-mediated lysis. In addition, neuroblastoma cells expressed B7-H3 (CD276), another surface molecule that inhibits NK cell function. Finally, this tumor did not express the PVR (CD155) and nectin-2 (CD112) ligands for the DNAM-1 activating NK receptor, which plays a crucial role in NK/neuroblastoma interactions. Altogether, these findings indicate that the neuroblastoma cells of this patient express an NK-resistant surface phenotype, which is at least in part similar to that previously described in a fraction of childhood neuroblastoma.

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Primary Ovarian Neuroblastoma

Cited by 6 publications

References 18 publications

Primitive neuroectodermal tumor of genital tract in hysterectomized patient: A case report

Primitive neuroectodermal tumor of genital tract in hysterectomized patient: A case report

Two cases of primary ovarian neuroblastoma arising from mature cystic teratomas

Primitive Neuroectodermal Tumor in an Ovarian Cystic Teratoma: Natural Killer and Neuroblastoma Cell Analysis

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