Primary Pancreatic Lymphoma

Abstract

Obtaining specimens through surgery is an effective diagnostic tool. Surgical resection in combination with postoperative chemotherapy plays a therapeutic role.

Primary Pancreatic Lymphoma Simulating Acute Cholestatic Hepatitis in a 7-Year-Old Child

“…PPL is extremely rare, both in adults and children, with only limited case reports or small case series available in world literature; it accounts for <1% of extranodal lymphomas and 0.7% of all pancreatic malignancies. 4 - 9 , 11 PPL is an extranodal lymphoma arising in the pancreas, with bulk of the tumor localized to the pancreas. 4 Standard diagnostic criteria include: 1) neither superficial lymphadenopathy nor enlargement of mediastinal lymph nodes on chest radiography, 2) a normal leukocyte count in peripheral blood, 3) main mass in the pancreas with lymph nodal involvement confined to peripancreatic region, and 4) no hepatic or splenic involvement.…”

The Spectrum of Hematologic Malignancies Involving the Pancreas

“…This manifestation can rarely result in resections that are likely not indicated because hematologic malignancies are generally treated medically with surgical management limited to cases necessitating secondary symptom control. [23][24][25][26][27][28][29][30][31][32] We identified 42 cases of hematologic malignancies involving the pancreas from surgical and cytologic material during a 45-year period and an additional 20 cases from autopsies performed during 20 years, encompassing a diverse spectrum. DLBCL accounted for the majority (~67% surgical/ cytologic cases; ~75% autopsy cases) of hematologic malignancies manifesting as pancreatic masses and those showing secondary involvement of the pancreas.…”

Primary Pancreatic Lymphoma in a Patient with Maturity Onset Diabetes of the Young type 3

“…So far less than two hundred cases have been described in literature consisting mainly in case reports or small case series 3. The etiology is unknown and no association have been described with common viral agents involved in the development of malignant lymphoma.…”