Primary polydipsia in thyrotoxicosis

Evered, D.C.; Hayter, C. J.; Surveyor, Ivor

doi:10.1016/0026-0495(72)90052-2

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…Evered et al suggested that urinary frequency in hyperthyroid patients may be a consequence of polyuria [28]. Hyperthyroidism is also associated with hyperdynamic circulation, which results in increased renal blood flow and an increased incidence of polyuria [29].…”

Section: Discussionmentioning

confidence: 99%

Bladder Pain Syndrome/Interstitial Cystitis Is Associated with Hyperthyroidism

et al. 2013

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BackgroundAlthough the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC) is still unclear, a common theme with BPS/IC patients is comorbid disorders which are related to the autonomic nervous system that connects the nervous system to end-organs. Nevertheless, no study to date has reported the association between hyperthyroidism and BPS/IC. In this study, we examined the association of IC/BPS with having previously been diagnosed with hyperthyroidism in Taiwan.DesignData in this study were retrieved from the Longitudinal Health Insurance Database. Our study consisted of 736 female cases with BPS/IC and 2208 randomly selected female controls. We performed a conditional logistic regression to calculate the odds ratio (OR) for having previously been diagnosed with hyperthyroidism between cases and controls.ResultsOf the 2944 sampled subjects, there was a significant difference in the prevalence of prior hyperthyroidism between cases and controls (3.3% vs. 1.5%, p<0.001). The conditional logistic regression analysis revealed that compared to controls, the OR for prior hyperthyroidism among cases was 2.16 (95% confidence interval (CI): 1.27∼3.66). Furthermore, the OR for prior hyperthyroidism among cases was 2.01 (95% CI: 1.15∼3.53) compared to controls after adjusting for diabetes, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma.ConclusionsOur study results indicated an association between hyperthyroidism and BPS/IC. We suggest that clinicians treating female subjects with hyperthyroidism be alert to urinary complaints in this population.

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Section: Discussionmentioning

confidence: 99%

Bladder Pain Syndrome/Interstitial Cystitis Is Associated with Hyperthyroidism

et al. 2013

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“…2 These systemic hemodynamic alterations are associated with increased renal hemodynamics and urine flow. 3,4 Both patients 5 and animals 6 with thyrotoxicosis may demonstrate polydipsia and polyuria. The mechanisms for the polyuria associated with thyrotoxicosis, however, have not been well defined.…”

mentioning

confidence: 98%

“…In this regards, the sensation of thirst has been shown to occur at a lower serum osmolality in thyrotoxicosis than the euthyroid state. 5,7 Alteration in systemic hemodynamics during hyperthyroidism could lead to non-osmotic suppression of arginine vasopressin (AVP) with resulting polyuria. A role of increased solute excretion, a known cause of polyuria, also needs to be considered.…”

mentioning

confidence: 99%

Polyuria of thyrotoxicosis: Downregulation of aquaporin water channels and increased solute excretion

Wang

Summer

et al. 2007

Kidney International

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Thyrotoxicosis is a common disorder causing cardiovascular and renal irregularities. In this study, thyrotoxicosis was produced in rats by 14 days of daily thyroxine injection. This was associated with an increase in cardiac index, mean arterial pressure, and renal blood flow compared with euthyroid controls. Food and water intake along with urine output were significantly increased in the thyrotoxic rats compared with control animals associated with a significant increase in solute excretion. Polyuria and increased solute excretion still occurred even when food and water intake was equivalent. These renal responses were associated with significant decreases in AQP1 and AQP2 water channel expression in both the ad lib and paired intake studies in the cortex and inner medulla. The downregulation of AQP2 protein occurred in spite of equivalent plasma arginine vasopressin (AVP) in the ad lib and increased AVP in the paired feeding studies. Solute-free water reabsorption was greater in both the ad lib and paired thyrotoxic than euthyroid rats and was associated with increased Na-K-2Cl cotransporter expression. We propose that the AVP-independent downregulation of AQP2, the observed increase in renal arterial pressure, and decrease in filtration fraction contribute to polyuria the increased solute excretion in spite of enhanced ion transporters in thyrotoxicosis.

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“…Polydipsia has been described as a presenting feature of hyperthyroidism in adults 4 . Studies have shown that hyperthyroid patients have increased micturition frequency as well as nocturia when compared to patients who are not hyperthyroid 5 .…”

Section: Discussionmentioning

confidence: 99%

Serendipitous Identification of Graves' Disease in Identical Twins with Polydipsia

Goldyn

Eugster

Nebesio

2010

Journal of Pediatric Endocrinology and Metabolism

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Graves’ disease in adolescents and adults usually presents with classic symptoms including weight loss, frequent stools, irritability, and heat intolerance. However, the clinical manifestations of hyperthyroidism in young children are often subtle, unrecognized, and atypical. Here, we report a 6 year-old girl who presented for evaluation of increased thirst. Review of systems was negative with respect to weight loss, irritability, palpitations, diarrhea, and school performance problems. Physical exam was unremarkable except for an enlarged thyroid gland. Her identical twin sister, who incidentally accompanied her to clinic, also had a previously unidentified goiter. Testing for diabetes was negative. Further laboratory investigation was consistent with Graves’ disease in both girls. Polydipsia is a rare and unusual presenting feature of hyperthyroidism in children. The evolution of this case highlights the importance of maintaining a high index of suspicion for thyroid disease during childhood.

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Primary polydipsia in thyrotoxicosis

Cited by 15 publications

References 24 publications

Bladder Pain Syndrome/Interstitial Cystitis Is Associated with Hyperthyroidism

Bladder Pain Syndrome/Interstitial Cystitis Is Associated with Hyperthyroidism

Polyuria of thyrotoxicosis: Downregulation of aquaporin water channels and increased solute excretion

Serendipitous Identification of Graves' Disease in Identical Twins with Polydipsia

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