Serendipitous Identification of Graves' Disease in Identical Twins with Polydipsia

Goldyn, Andrea K.; Eugster, Erica A.; Nebesio, Todd D.

doi:10.1515/jpem.2010.208

Cited by 5 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from the present case and the recent case reports with Graves’ disease in twins [5-7], the combination of Graves’ disease and primary hypothyroidism in female twins has also been reported [19,20]. Aust et al described twins where simultaneously Graves’ disease and Hashimoto’s thyroiditis occurred in monozygotic twins [19].…”

Section: Discussionmentioning

confidence: 48%

“…There are data from epidemiological, family, and twin studies demonstrating a strong genetic influence on the development of autoimmune thyroid diseases [3,4]. The rare situation of hyperthyroidism with Graves’ disease in twins has been reported in a very few case reports in literature [5-7]. Goldyn et al described the serendipitous and simultaneous case of Graves’ disease in 6-year old female twins [5].…”

Section: Introductionmentioning

confidence: 99%

“…The rare situation of hyperthyroidism with Graves’ disease in twins has been reported in a very few case reports in literature [5-7]. Goldyn et al described the serendipitous and simultaneous case of Graves’ disease in 6-year old female twins [5]. Mizukami et al reported the case of Graves’ disease in identical twins with mental disorder [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Graves’ disease in monozygotic twins – a case report

2013

View full text Add to dashboard Cite

BackgroundAutoimmune thyroid diseases including Graves’ disease and Hashimoto’s thyroiditis are caused by immune response to self-thyroid antigens. The rare situation of hyperthyroidism with Graves’ disease in twins has been reported in a very few case reports in literature.Case presentationWe present monozygotic female twins developing consecutively Graves’ disease within five years. One year before the diagnosis of Graves’ disease was established in the first twin, the mother developed a toxic thyroid nodule with hyperthyroidism leading to hemi thyroidectomy. Both the mother and the twins were cigarette smokers. The twins were treated with carbamizole and this therapy led to normalization of thyroid stimulating hormone and thyroxine.ConclusionThis case report supports the hypothesis that a genetic factor as well as an environmental factor (cigarette smoking) might be of great importance in the aetiology of Graves’ disease.

show abstract

Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Graves’ disease in monozygotic twins – a case report

2013

View full text Add to dashboard Cite

show abstract

“…9–17 A delay in diagnosis is particularly common in prepubertal children, who have a propensity to present with atypical symptoms. 18 However, the frequency of spurious diagnoses and subspecialty evaluation in children ultimately diagnosed with GD has not been established. Although the signs and symptoms of GD are well established, to our knowledge, our study is the first to systematically examine previous evaluations and diagnoses in a large cohort of pediatric patients with GD.…”

Section: Discussionmentioning

confidence: 99%

Detours on the Road to Diagnosis of Graves Disease

Sims

Eugster

Nebesio

2011

Clin Pediatr (Phila)

Self Cite

View full text Add to dashboard Cite

Objectives The aims of this study were to determine the frequency at which spurious diagnoses and unnecessary treatment occurs prior to the diagnosis of Graves disease (GD) and to evaluate the economic consequences of these events. Methods Retrospective chart review of children diagnosed with GD. Results A total of 76 children (61 girls) aged 11.9 ± 3.8 years were identified. In all, 17 (22.4%) were referred to other subspecialists prior to diagnosis of GD. Six were hospitalized, and 2 visited emergency rooms. A total of 15 (19.7%) underwent nonthyroid-related studies. Estimated cost of testing and procedures ranged from $49 to $14 000. Twelve (15.8%) were diagnosed with attention deficit/hyperactivity disorder, and 16 (21.1%) were started on medications for other conditions prior to diagnosis of GD. Conclusions Evaluation and treatment for presumed other disorders are common in children with GD. A high index of suspicion for hyperthyroidism by primary care providers may help to avoid clinical detours that may be costly and delay diagnosis.

show abstract

“…Polydipsia has been described as a presenting symptom of hyperthyroidism in adults. A few years back a serendipitous identification of GD in identical twin girls with polydipsia was published [9]. Though etiology of nocturnal enuresis is not fully understood, evidence is growing that enuresis may have a central origin: bedwetting children have lower brainstem reflex control (impaired prepulse inhibition) than normal controls [10].…”

Section: Polydipsia Nocturnal Enuresismentioning

confidence: 99%

Unusual Presentation and Rare Comorbidity of Graves-Basedow’s Disease in Children

Muzsnai¹

2021

Graves' Disease

View full text Add to dashboard Cite

Graves’-Basedow’s disease (GD) is a well-defined hyperthyroid disorder caused by circulating antibodies that results the overproduction of thyroid hormones. All but a few children present with some degree of thyroid gland enlargement and most have two or more signs of excessive thyroid activity, such as tremor, irritability/nervousness, tachycardia etc. Fully developed clinical picture is easy to recognize while often the onset is insidious. Thyroid hormones affect many body systems, so signs and symptoms of Graves’ disease can be wide ranging. A survey on PubMed literature was conducted to gather all published pediatric Graves-Basedow’s cases with unusual presentation at the time of diagnosis. We found all together 70 manuscripts with relevant information from 1978 to 2020 but mainly adult cases. One third of them were found to meet the criteria we focused on and were included in this paper, though in some situation the unusual findings do not consist part of hyperthyroidism, the rare manifestation is only a coexistence, or the serious disease even precedes the GD. Dermatopathy, hepatic dysfunction, impaired fluid balance, concomitant disorders in thyrotoxicosis, tricky laboratory findings, a phenomenon of metamorphic thyroid autoimmunity, peculiarities of thyroid dysfunction in children with Down syndrome, apparent associations, and reconstitution GD are highlighted in this chapter. Awareness about the relation of these remote findings to GD, or frequent coexistence with GD is important for early diagnosis. Finally, a reasonable suspicion for Graves’ disease may ultimately help to prevent unnecessary investigations and treatment.

show abstract

Serendipitous Identification of Graves' Disease in Identical Twins with Polydipsia

Cited by 5 publications

References 11 publications

Graves’ disease in monozygotic twins – a case report

Graves’ disease in monozygotic twins – a case report

Detours on the Road to Diagnosis of Graves Disease

Unusual Presentation and Rare Comorbidity of Graves-Basedow’s Disease in Children

Contact Info

Product

Resources

About